血必净联合乌司他丁治疗重症脓毒症的效果  

Effect of Xuebijing Combined With Ulinastatin in the Treatment of Severe Sepsis

作　　者：王浩 朱旭刚 孙瑞 赵明峰[3] WANG Hao;ZHU Xugang;SUN Rui;ZHAO Mingfeng(ICU of Tianjin Hospital,Tianjin 300000,China;ICU of Zhuanglang County People’s Hospital,Zhuanglang 744699,Gansu,China;Department of Hematology,Tianjin First Central Hospital,Tianjin 300192,China)

机构地区：[1]天津市天津医院ICU,天津300000 [2]庄浪县人民医院ICU,甘肃庄浪744699 [3]天津市第一中心医院血液科,天津300192

出　　处：《中国药物滥用防治杂志》2024年第9期1700-1703,1707,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：天津市天津医院院级科研基金项目(编号:TJYY1808);北京医卫健康公益基金项目(编号:YWJKJJHKYJJTYU123F)。

摘　　要：目的:研究在重症脓毒症患者的临床治疗中实施血必净联合乌司他丁治疗的临床疗效。方法:以2016年8月—2022年10月我院接诊的重症脓毒症患者66例为研究对象进行回顾性研究,根据治疗方式不同分为对照组(n=33)和观察组(n=33)。对照组予以血必净单药治疗,观察组予以血必净联合乌司他丁治疗,比较两组治疗后机械通气时间、ICU住院时间、APACHEⅡ评分、肿瘤坏死因子α(TNF-α)、降钙素原浓度(PCT)、血浆脂多糖(LPS)、炎性因子改善情况。结果:观察组机械通气时间、ICU住院时间短于对照组(P<0.05);观察组治疗后第3天和第7天APACHEⅡ评分低于对照组(P<0.05);观察组治疗后LPS、TNF-α、IL-6、hs-CRP、PCT低于对照组(P<0.05)。结论:在重症脓毒症治疗中,血必净联合乌司他丁具有良好的抗炎作用,能够改善患者生理健康状况,缩短机械通气时间及ICU住院时间,临床应用价值较高。Objective:To study the clinical efficacy of Xuebijing combined with ulinastatin in the clinical treatment of patients with severe sepsis.Methods:A retrospective study was conducted on 66 patients with severe sepsis admitted to our hospital from August 2016 to October 2022.They were divided into control group(n=33)and observation group(n=33)according to different treatment methods.The control group was treated with Xuebijing alone,and the observation group was treated with Xuebijing combined with ulinastatin.The improvement of mechanical ventilation time,ICU hospitalization time,APACHEⅡscore,tumor necrosis factor-α(TNF-α),procalcitonin concentration(PCT),plasma lipopolysaccharide(LPS)and inflammatory factors were compared between the two groups after treatment.Results:The mechanical ventilation time and ICU hospitalization time in the observation group were shorter than those in the control group(P<0.05).The APACHEⅡscore of the observation group was lower than that of the control group on the 3 rd and 7 th day after treatment(P<0.05).After treatment,LPS,TNK-α,IL-6,hs-CRP and PCT in the observation group were lower than those in the control group(P<0.05).Conclusion:In the treatment of severe sepsis,Xuebijing combined with ulinastatin has a good anti-inflammatory effect,which can improve the physiological health status of patients,shorten the mechanical ventilation time and ICU hospitalization time,and has high clinical application value.

关 键 词：血必净 乌司他丁 重症脓毒症 临床研究 

分 类 号：R459.7[医药卫生—急诊医学]