可见光光学相干层析成像技术发展综述(特邀)  

Development of Visible-Light OCT:A Review(Invited)

作　　者：宋维业 姚政开 吴付旺 户凯旋 姜显春 Song Weiye;Yao Zhengkai;Wu Fuwang;Hu Kaixuan;Jiang Xianchun(School of Mechanical Engineering,Shandong University,Jinan 250061,Shandong,China;Key Laboratory of High Efficiency and Clean Mechanical Manufacture of Ministry of Education,Shandong University,Jinan 250061,Shandong,China)

机构地区：[1]山东大学机械工程学院,山东济南250061 [2]山东大学高效洁净机械制造教育部重点实验室,山东济南250061

出　　处：《中国激光》2024年第15期1-14,共14页Chinese Journal of Lasers

摘　　要：光学相干层析成像技术是一种高分辨率、高信噪比的非接触式三维成像技术,在视网膜成像等领域具有重要的应用价值与意义。可见光光学相干层析成像技术采用波长更短的光源,相比于采用传统的近红外波段光源具有独特的成像优势——可以达到亚微米级的轴向分辨率,具有更高的视网膜层间对比度,可以检测视网膜血管的血氧饱和度——对多种疾病的早期诊断、治疗和深入研究具有重要意义。本文简述了光学相干层析成像技术的发展现状,并对可见光光学相干层析成像技术在系统结构优化、动物成像应用和临床应用方面的代表性工作进行了综述。Significance Optical coherence tomography(OCT)technology was proposed in 1991.Based on the principle of low-coherence light interference,OCT features high resolution and a high signal-to-noise ratio;it is also non-invasive,non-destructive,and capable of three-dimensional imaging.It enables the imaging of microstructures within biological tissues,with significant application potential in fields such as biology,medicine,and materials.Consequently,it stands as one of the focal points in modern optical imaging research.The resolution plays a crucial role in the assessment of OCT because it directly impacts the image quality,thereby influencing the accuracy of disease diagnosis and condition assessment by medical professionals.Therefore,the pursuit of high resolution has been one of the primary directions in the development of OCT technology.Vis-OCT,which utilizes visible light with shorter wavelengths for imaging,offers higher lateral and axial resolution,enabling a finer depiction of microstructures within biological tissues.In comparison to NIR-OCT,which is commonly used in hospitals,Vis-OCT not only provides higher image resolution but also yields images with higher contrast,thereby revealing more information about biological tissues.The high resolution and contrast of Vis-OCT make it promising for widespread applications in fields such as ophthalmology and dermatology.By providing doctors with more detailed and precise image information,it facilitates more accurate observations and diagnoses of pathological tissues.Additionally,Vis-OCT can quantify sO 2 through spectral analysis,providing a powerful tool for assessing retinal blood circulation and oxygen metabolism.Lastly,because the wavelength of visible light falls within the sensing spectrum of the retina,there may be a more direct relationship between the structure and function of the retina that can be observed by Vis-OCT,making these advantages worthy of further research.In practical applications,researchers have already conducted studies using Vis-OCT for

关 键 词：光学相干层析成像 可见光 成像系统 视网膜成像 血氧饱和度检测 

分 类 号：TN247[电子电信—物理电子学]