脂质代谢对子宫内膜容受性及胚胎着床影响的研究进展  

Research progress on the impact of lipid metabolism on endometrial receptivity and embryo implantation

作　　者：马丽娜 秦莹[1] 王克华[3] 庞聪慧[3] 卢利歌 袁温鲜 张多加[5] 吴效科[5] Ma Li-Na;Qin Ying;Wang Ke-Hua;Pang Cong-Hui;Lu Li-Ge;Yuan Wen-Xian;Zhang Duo-Jia;Wu Xiao-Ke(Department of Obstetrics,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014,China;Post Doctoral Station of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250000,China;Department of Reproduction and Genetics,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014,China;Graduate School of Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040,China;Department of Gynecology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040,China)

机构地区：[1]山东中医药大学附属医院产科,山东济南250014 [2]山东中医药大学博士后流动站,山东济南250000 [3]山东中医药大学附属医院生殖与遗传科,山东济南250014 [4]黑龙江中医药大学研究生院,黑龙江哈尔滨150040 [5]黑龙江中医药大学附属第一医院妇科,黑龙江哈尔滨150040

出　　处：《解放军医学杂志》2024年第9期1088-1093,共6页Medical Journal of Chinese People's Liberation Army

基　　金：国家重点研发计划项目(2019YFC1709500);国家重大疑难疾病中西医临床协作试点项目(国中医药办医政发[2018]3号);黑龙江省“头雁”团队-中西医结合妇科特色技术创新团队(黑政规[2019]2号)。

摘　　要：脂类包括脂肪(三酰甘油)及类脂(磷脂、固醇类),除为机体提供能量外,脂质代谢也在整个生殖过程中发挥重要作用,尤其是早期妊娠的建立和维持(包括调节早期胚胎的发育和子宫的容受性,以及促进胚胎的着床)阶段。鉴于脂质种类繁多,本文着重从多不饱和脂肪酸、内源性大麻素、前列腺素、溶血磷脂酸、鞘磷脂、类固醇激素等被广泛研究的脂质介质,系统阐述脂肪酸、磷脂、胆固醇代谢对子宫内膜容受性形成及胚胎着床的调控作用,以及可能的潜在机制,以期为预测和改善自然妊娠和(或)辅助生殖助孕的结局提供新的切入点及可行的干预途径。Lipids,including fats(triglycerides) and lipoids(phospholipids and sterols),not only serve as an energy source for the body but also play a pivotal role throughout the reproductive process,particularly in the establishment and maintenance of early pregnancy.This encompasses the regulate of early embryonic development and uterine tolerance,and the facilitation of embryo implantation.Given the diversity of lipids,this review focuses on extensively studied lipid mediators such as polyunsaturated fatty acids,endocannabinoids,prostaglandins,lysophosphatidic acid,sphingolipids and steroid hormones.It systematically elaborates on the regulatory effects of fatty acid,phospholipid,and cholesterol metabolism on the formation of endometrial receptivity and embryo implantation,as well as the potential underlying mechanisms.The review aims to provide new insights and feasible intervention approaches for predicting and improving the outcomes of natural pregnancy and/or assisted reproductive technology.

关 键 词：脂类代谢 子宫内膜容受性 着床 前列腺素 内源性大麻酚类 

分 类 号：R711.5[医药卫生—妇产科学]