羧甲基纤维素棕榈酸酯的合成及其胶束包载姜黄素研究  

Study on Synthesis of Carboxymethyl Cellulose Palmitate and Encapsulation of Curcumin in Its Micelle

作　　者：刘艺莹 王洋 Liu Yiying;Wang Yang(Guangzhou Huashang Vocational College,Guangdong,511300;South China Agricultural University,Guangdong,510642)

机构地区：[1]广州华商职业学院,广东511300 [2]华南农业大学,广东510642

出　　处：《当代化工研究》2024年第18期172-174,共3页Modern Chemical Research

基　　金：广东省重点领域研发计划项目子课题“纤维素脂肪酸酯基水基化农药制剂研发”(项目编号:2023B0202080001-1-3)。

摘　　要：以羧甲基纤维素和棕榈酸为原料,合成具有两亲性的羧甲基纤维素棕榈酸酯,以其在水相中自组装形成的胶束作为载体对姜黄素进行包载。通过红外光谱验证了羧甲基纤维素棕榈酸酯的成功合成,激光粒度仪测试则证明载药胶束纳米乳液的形成,采用液相色谱测试并计算了载药胶束的载药量及包封率。本研究以全生物基载体实现了疏水姜黄素在水中的稳定分散。Amphiphilic carboxymethyl cellulose palmitate was synthesized using carboxymethyl cellulose and palmitic acid,and self-assembled in aqueous phase to load curcumin.The successful synthesis of carboxymethyl cellulose palmitate was verified by infrared spectrum,and the laser particle size analysis proved the formation of drug-loaded micellar nanoparticles.The loading capacity and encapsulation efficiency of the drug-loaded micelles were calculated by liquid chromatography test.This study achieved stable dispersion of hydrophobic curcumin in aqueous phase using all-bio-based carrier.

关 键 词：两亲性聚合物 纤维素衍生物 姜黄素 载药胶束 

分 类 号：O636.1[理学—高分子化学]