水飞蓟素(双宾30%/水飞蓟素80%)蒸发结晶工艺研究  

Study on Evaporative Crystallization Process of Silymarin(Silybin and Isosilybin 30%/Silymarin 80%)

作　　者：赵文行 乔宣宣 牛志平 武耐英 高伟 ZHAO Wenxing;QIAO Xuanxuan;NIU Zhiping;WU Naiying;GAO Wei(College of Materials Science and Engineering,Hebei of Engineering,Hebei Handan 056038;Chenguang Biotech Group Co.,Ltd.,Hebei Handan 057250;Key Laboratory of Plant Resources Comprehensive Utilization of Hebei Province,Hebei Handan 057250,China)

机构地区：[1]河北工程大学材料科学与工程学院,河北邯郸056038 [2]晨光生物科技集团股份有限公司,河北邯郸057250 [3]河北省植物资源综合利用重点实验室,河北邯郸057250

出　　处：《广州化工》2024年第19期56-60,共5页GuangZhou Chemical Industry

基　　金：河北省科技重大专项(京津冀重大科技成果转化)(19047144Z);邯郸市科学技术研究与发展计划(21422012320)。

摘　　要：为获取水飞蓟双宾(水飞蓟宾、异水飞蓟宾)液相含量30%、水飞蓟素紫外含量80%产品最佳收率的操作工艺,对不同提取及纯化条件下产品进行研究。研究了溶剂、料液比和温度对水飞蓟双宾提取率的影响。通过正交实验设计优化纯化工艺,确定最佳工艺为:浓缩温度50℃、浓缩真空度0.07 MPa、转速50 r/min、蒸发终点水飞蓟素溶质/溶液质量比0.20,制备的产品水飞蓟双宾液相含量为36.66%、水飞蓟素紫外含量为86.02%,水飞蓟双宾含量收率为98.57%,产品粒径D 50为37.64μm。In order to obtain the optimum yield of silybin and isosilybin products with liquid content of 30%and silymarin UV content of 80%,the products were studied under different extraction and purification conditions.The effects of solvent,solid-liquid ratio and temperature on the extraction rate of silybin and isosilybin were studied.By optimizing the purification process through orthogonal experimental design,the optimal process was determined as follows:concentration temperature was 50℃,concentration vacuum was 0.07 MPa,rotation speed was 50 r/min,evaporation end point of silymarin solute solution mass ratio was 0.20.Under the optimal conditions,the liquid content of silybin and isosilybin and UV content of silymarin were 36.66%and 86.02%,respectively.The yield of silybin content was 98.57%,and the product particle size D 50 was 37.64μm.

关 键 词：水飞蓟素 水飞蓟宾 异水飞蓟宾 蒸发结晶 正交实验 

分 类 号：TQ461[化学工程—制药化工]