柠檬醛连续合成假性紫罗兰酮新工艺  

A New Technique for Continuous Synthesis of Pseudoionone from Citral

作　　者：李春亮 翟德伟 郭佳 沈彩云 陈加琪 梁丽娜 刘学军[1] LI Chunliang;ZHAI Dewei;GUO Jia;SHEN Caiyun;CHEN Jiaqi;LIANG Lina;LIU Xuejun(College of Chemical Engineering,Zhejiang University of Technology,Huzhou 313000,China;Zhejiang Fangyuanxin Bio-Pharmaceutical Co.,Ltd.,Shaoxing 311800,China;Zhejiang Medicine Co.,Ltd.Changhai Biological Company,Shaoxing 311800,China;Keqiao Enviromental Protection Burear of Shaoxing,Shaoxing 311800,China;Zhejiang Anglikang Pharmaceutical Co.,Ltd.,Shaoxing 311800,China)

机构地区：[1]浙江工业大学化学工程学院,浙江湖州313000 [2]浙江芳原馨生物医药有限公司,浙江绍兴311800 [3]浙江医药股份有限公司昌海生物分公司,浙江绍兴311800 [4]绍兴市柯桥区环境保护局,浙江绍兴311800 [5]浙江昂利康制药股份有限公司,浙江绍兴311800

出　　处：《化工管理》2024年第26期144-147,共4页Chemical Management

摘　　要：工业上假性紫罗兰酮的合成多为间歇式,选择性较低,利用振荡连续流反应器,考察振荡频率、停留时间、反应温度、氢氧化钠用量、丙酮与柠檬醛摩尔比等因素对合成假性紫罗兰酮的影响。结果表明:当振荡频率300 r/min,停留时间1.5 h,反应温度35℃,氢氧化钠用量(质量分数)为1%,丙酮与柠檬醛摩尔比为14∶1时,假性紫罗兰酮的转化率达到了98%,选择性达到了94%。该反应器可以实现假性紫罗兰酮的连续反应。The industrial synthesis of pseudoionone is mostly intermittent with low selectivity.The effects of oscillation frequency,residence time,reaction temperature,sodium hydroxide dosage and molar ratio of acetone to citral on the synthesis of pseudoionone were investigated in an oscillating continuous f low reactor.The results showed that the conversion rate of pseudoionone reached 98%and the selectivity reached 94%when the oscillation frequency was 300 r/min,the residence time was 1.5 h,the reaction temperature was 35℃,the amount of sodium hydroxide(mass fraction)was 1%,and the molar ratio of acetone to citral was 14∶1.The reactor can realize the continuous reaction of pseudoionone.

关 键 词：假性紫罗兰酮 柠檬醛 振荡反应器 合成工艺 化学品 

分 类 号：TQ07[化学工程]