通窍鼻炎颗粒治疗变应性鼻炎疗效的系统评价  

Meta analysis on the efficacy and safety of Tongqiao Biyan Granule in the treatment of allergic rhinitis

作　　者：王咏丽 安淇 李红梅[1] 吕小红 张忠梅 张霞[1] 刘红梅[1] WANG Yongli;AN Qi;LI Hongmei;LV Xiaohong;ZHANG Zhongmei;ZHANG Xia;LIU Hongmei(General Medicine Department of the Northern Medical District,PLA General Hospital,Beijing,100094,China)

机构地区：[1]中国人民解放军总医院京北医疗区综合内科,北京100094 [2]中国人民解放军总医院京北医疗区门诊部,北京 [3]中国人民解放军总医院京北医疗区医技保障科,北京

出　　处：《中国中西医结合耳鼻咽喉科杂志》2024年第5期346-349,379,共5页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的系统分析评价通窍鼻炎颗粒治疗变应性鼻炎的有效性和安全性。方法检索Pubmed、CBM、CNKI、VIP和万方等数据库,搜集2010年1月至2020年12月发表的通窍鼻炎颗粒治疗变应性鼻炎文献,应用RevMan5.3软件进行系统评价。结果共纳入11篇研究报告,包括1072例患者,其中通窍鼻炎颗粒联合常规疗法治疗组533例,单纯应用常规疗法治疗组539例。Meta分析显示,联合治疗组临床症状总评分[MD=-1.88,95%CI(-2.67--1.09),P<0.00001]、总有效率[MD=0.14,95%CI(0.09-0.18),P<0.00001]均优于对照组,患者血清IL-4水平改善幅度[MD=-1.68,95%CI(-2.08--1.28),P<0.00001]明显大于对照组;两组患者均未见明显不良反应无差异。结论通窍鼻炎颗粒联合常规疗法治疗变应性鼻炎的疗效优于单用常规疗法治疗,安全性良好。Objective To systematically evaluate the efficacy and safety of Tongqiao Biyan Granule(TQBYG)in the treatment of allergic rhinitis.Methods According to the Cochrane systematic evaluation method,searched databases were Pubmed,CBM,CNKI,VIP,WanFang and so on to collect randomized controlled trials(RCT)on TQBYG in the treatment of allergic rhinitis(AR)from Jan.2010 to Dec.2020.Then,RevMan 5.3 software was used for Meta-analysis on these reports.Results A total of 11 RCTs were collected,including 1072 subjects in total,with 533 cases in the combined therapy group(CTG)with TQBYG plus routine treatment procedure and 539 in the routine treatment procedure group(RTPG).Then,Meta-analysis was carried out on these trials and the results showed that the total clinical symptom score[MD=-1.88,95%CI(-2.67--1.09),P<0.00001]and the effective rate[MD=0.14,95%CI(0.09-0.18),P<0.00001]of cases in CTG were significantly superior to RTPG,with the improving amplitude of serum IL-4 level[MD=-1.68,95%CI(-2.08--1.28),P<0.00001]in CTG was also obviously larger than that in RTPG as well.However,there were no statistically significant difference in the side effects between these two groups.Conclusion The therapy combined Tongqiao Biyan Granule with routine treatment procedure should be better in its therapeutic effects than that of simple routine treatment procedure for allergic rhinitis.

关 键 词：变应性鼻炎 通窍鼻炎颗粒 疗效 安全性 META分析 

分 类 号：R276.1[医药卫生—中医五官科学]