新孢子虫入侵对宿主细胞炎症反应与应答的调节  

Regulation of Host Cell Inflammation and Immune Response to Neospora caninum Invasion

作　　者：刘禹馨 贾芮 于龙政[1,2] LIU Yu-xin;JIA Rui;YU Long-zheng(College of Agriculture,Yanbian University,Yanji,Jilin 133000,China;Engineering Research Center of Beef Cattle Science and Technology Innovation of the Ministry of Education in Northeast Cold Region,Yanji,Jilin 133000,China)

机构地区：[1]延边大学农学院,吉林延吉133000 [2]东北寒区肉牛科技创新教育部工程研究中心,吉林延吉133000

出　　处：《动物医学进展》2024年第11期100-105,共6页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(32060807);吉林省教育厅“十三五”科学技术项目(JJKH20200522KJ);高等学校学科创新引智计划项目(D20034)。

摘　　要：犬新孢子虫是一种寄生在动物细胞内的原虫,可引起新孢子虫病。该病临床表现为母牛的繁殖障碍,导致其流产或死胎,严重影响养殖业的正常发展。新孢子虫病广泛分布世界各地,但由于新孢子虫感染与宿主之间相互作用的机制尚未阐明,尚未研制出特效的药物与商品化疫苗。有研究表明,在虫体入侵宿主的过程中,宿主的天然免疫在抵抗新孢子虫感染中的作用不可忽视。论文主要阐述了犬新孢子虫入侵对宿主细胞免疫调节的影响以及虫体分泌的外泌体在新孢子虫入侵过程中的作用,为深入了解犬新孢子虫的致病机制以及新孢子虫病防治提供新的思路。Neospora canninum is a protozoan parasite that parasitizes in animal cells and can cause neosporosis.The clinical manifestations of the disease are reproductive disorders in cows,leading to abortion or stillbirth,which seriously affects the normal development of the breeding industry.N.caninum is widely distributed all over the world.However,due to the mechanism of interaction between N.caninum infection and host has not been elucidated,specific drugs and commercial vaccines have not been developed.Studies have shown that the role of the host's natural immunity in resisting N.caninum infection cannot be ignored in the process of the parasite invading the host.This article mainly describes the effect of N.caninum invasion on the immune regulation of host cells and the role of exosomes secreted by parasites in the process of N.caninum invasion.It provides new ideas for in-depth understanding of the pathogenic mechanism of N.caninum and the prevention and treatment of N.caninum infection.

关 键 词：犬新孢子虫 感染 宿主细胞 相互作用 免疫调控 

分 类 号：S855.9[农业科学—临床兽医学] S852.72[农业科学—兽医学]