基于结构力学和流体动力学分析的HfO_(2)空心微针结构研究及评价  

Study and evaluation of HfO_(2) hollow microneedle structure based on structural mechanics and fluid dynamics analysis

作　　者：魏静 邱珍珍 周瑞[1] WEI Jing;QIU Zhenzhen;ZHOU Rui(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488)

机构地区：[1]北京中医药大学中药学院,北京102488

出　　处：《北京生物医学工程》2024年第5期493-499,共7页Beijing Biomedical Engineering

基　　金：北京中医药大学校级重点研发课题(2020-JYB-ZDGG-050);国家中医药管理局高水平建设学科(ZYYZDXK-2023272)资助。

摘　　要：目的研究不同尖端尺寸HfO_(2)空心微针(hollow microneedle,HMN)的结构力学性能和HfO_(2)空心微针流体力学性能,以增强HfO_(2)空心微针的穿刺性能,减少给药过程中液体药物的损耗,并提高空心微针给药的精准性。方法针对HfO_(2)空心微针长度(L=250μm、350μm、500μm)、直径(D_(b)=150μm、200μm、250μm)以及针尖直径(D_(t)=10μm、20μm、30μm)进行正交设计得到9组HMN的尺寸参数组合,并进行结构力学分析,选出最优外形的HfO_(2)空心微针。对T形、120°Y形和60°Y形三种形状的管腔孔道进行流体动力学分析。在不同入口压力下,研究三种管腔内部流体的压力场、速度场分布,并分析3种管腔的流体速度损失,量化评估HfO_(2)空心微针孔道的流动性能。结果针对9组HfO_(2)空心微针的结构力学分析,结果显示微针长度为350μm、基底直径为200μm、尖端直径为20μm时,HfO_(2)空心微针能得到较高的安全系数并保持结构的稳定性,在穿刺过程中未发生失效。针对HfO_(2)空心微针的流体动力学研究,结果表明,60°Y形的HfO_(2)空心微针管腔,入口至出口处的速度损失最小。结论本文设计的HfO_(2)空心微针在满足安全要求的同时可实现穿刺性能优化,并减少流速损失和实现无堵塞给药,为后续降低实验研究相关的成本和时间提供指导。Objective The structural mechanic of HfO_(2) hollow microneedles(HMN)with different tip sizes and the hydrodynamic properties of HfO_(2) hollow microneedles were investigated in order to enhance the penetration performance of HfO_(2) hollow microneedles,to minimize the loss of liquid drug during drug delivery,and to improve the precision of drug delivery by hollow microneedles.Methods Nine combinations of HMN dimensions were obtained by orthogonal design for the length(L=250μm,350μm,and 500μm),diameter(D_(b)=150μm,200μm,and 250μm),and tip diameter(D_(t)=10μm,20μm,and 30μm)of the HfO2 hollow microneedles,and the optimal shape of the hollow microneedles was analyzed by structural mechanical analysis.The hydrodynamic analysis was carried out for the three shapes of T-shaped,120°Y-shaped and 60°Y-shaped luminal orifices.Under different inlet pressures,the pressure and velocity distributions of the fluids inside the three lumens were investigated,and the fluid velocity losses of the three lumens were analyzed to quantitatively evaluate the flow performance in the lumen.Results The structural mechanical analysis of nine groups of HfO_(2) hollow microneedles showed that with a microneedle length of 350μm,a base diameter of 200μm,and a tip diameter of 20μm,the HfO_(2) hollow microneedles were able to obtain a high safety coefficient and maintain the structural stability,and did not experience any failure during the puncture process.The fluid dynamics study of the HfO_(2) hollow microneedle showed that the velocity loss from the inlet to the outlet was minimized for the 60°Y shaped HfO_(2) hollow microneedle lumen.Conclusions The HfO_(2) hollow microneedle designed in this paper can optimize the puncture performance while meeting the safety requirements,as well as reduce the flow velocity loss and realize the non-clogging drug delivery,which provides guidance for the subsequent reduction of the cost and time associated with the experimental study.

关 键 词：空心微针 计算流体动力学 有限元分析 透皮给药 

分 类 号：R318.01[医药卫生—生物医学工程]