Apelin在女性生殖健康中的研究进展  

Research progress of Apelin in female reproductive health

作　　者：陈琳 李瑞雪 王宏羽 尹海燕 郭岩 CHEN Lin;LI Ruixue;WANG Hongyu;YIN Haiyan;GUO Yan(Clinical Medical College,Jining Medical University,Jining 272067,China;Basic Medical College,Jining Medical University,Jining 272067,China)

机构地区：[1]济宁医学院临床医学院,山东济宁272067 [2]济宁医学院基础医学院,山东济宁272067

出　　处：《基础医学与临床》2024年第10期1451-1454,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(82000979);济宁医学院2022年大学生创新训练计划项目(cx2022070z)。

摘　　要：Apelin是一种脂肪因子,包括Apelin-13、Apelin-36等多种亚型,通过参与免疫调节、氧化应激、糖脂代谢、细胞凋亡等调节生理功能。Apelin与多囊卵巢综合征、卵巢癌等女性生殖系统疾病密切相关,有望为此类疾病的进一步研究及治疗提供靶点与方向。Apelin is an adipokine family which includes Apelin-13,Apelin-36 and other isoforms and regulates physiological functions by immunomodulation,oxidative stress,glycolipid metabolism,and apoptosis and so on.Apelin is closely related to polycystic ovary syndrome,ovarian cancer and other diseases of the female reproductive system so it is expected to be new target molecules and may orient the development of research and clinical treatment.

关 键 词：APELIN 卵巢 颗粒细胞 脂肪因子 子宫内膜 

分 类 号：R339.2[医药卫生—人体生理学]