钯炭催化剂合成孕烯醇酮醋酸酯的性能研究  

Performance study on palladium-carbon catalyst forsynthesis of pregnenolone acetate

作　　者：翟康 张磊 王昭文 张鹏 李岳锋 Zhai Kang;Zhang Lei;Wang Zhaowen;Zhang Peng;Li Yuefeng(Xi’an Catalyst New Materials Co.,Ltd.,Xi’an 710201,Shaanxi,China;Shaanxi Engineering Research Center of Noble Metal Catalyst,Xi’an 710201,Shaanxi,China;Shaanxi Key Laboratory of Catalytic Materials and Technology,Xi’an 710201,Shaanxi,China)

机构地区：[1]西安凯立新材料股份有限公司,陕西西安710201 [2]陕西省贵金属催化剂工程研究中心,陕西西安710201 [3]陕西省催化材料与技术重点实验室,陕西西安710201

出　　处：《工业催化》2024年第9期63-67,共5页Industrial Catalysis

摘　　要：孕烯醇酮醋酸酯是合成孕激素类黄体酮药物重要的中间体。其合成工艺是以无水乙醇为溶剂,在5%Pd/C催化剂和H 2的作用下,双烯醇酮醋酸酯结构中16位上的碳碳双键(C=C)发生加氢反应,生成孕烯醇酮醋酸酯。实验结果表明,合成孕烯醇酮醋酸酯的最佳条件是:催化剂的用量为0.4 g,反应温度为45℃,反应时间为120 min,反应器转速大于500 r·min^(-1);载体经3%硝酸预处理,5%过硫酸铵改性,再经2.5%氯化镁改性,制得的催化剂反应性能最好。Pregnenolone acetate is an important intermediate in the synthesis of progesterone drugs.The synthesis process is based on anhydrous ethanol as solvent,under the action of 5%Pd/C catalyst and H 2,the carbon-carbon double bond(C=C)in the structure of dienolone acetate is hydrogenated to produce pregnenolone acetate.The results showed that the optimum conditions for the synthesis of pregnenolone acetate were as follows:the amount of catalyst was 0.4 g,the reaction temperature was 45℃,the reaction time was 120 min,and the reactor speed was greater than 500 r·min^(-1).The carrier was pretreated with 3%nitric acid,modified with 5%ammonium persulfate,and then modified with 2.5%magnesium chloride to produce a catalyst with the best reaction performance.

关 键 词：精细化学工程 孕烯醇酮醋酸酯 双烯醇酮醋酸酯 钯炭催化剂 

分 类 号：TQ426.94[化学工程] TQ225.241