D-半乳糖结晶母液的脱色工艺  

Decolorization process of D-galactose crystallization mother liquor

作　　者：赵鹏 刘畅 王永锋 陆丹丹 浦军平 张春枝[1] ZHAO Peng;LIU Chang;WANG Yongfeng;LU Dandan;PU Junping;ZHANG Chunzhi(School of Biological Engineering,Dalian Polytechnic University,Dalian 116034,China;Zhangjiagang Huachang Pharmaceutical Company Limited,Suzhou 215600,China)

机构地区：[1]大连工业大学生物工程学院,辽宁大连116034 [2]张家港市华昌药业有限公司,江苏苏州215600

出　　处：《大连工业大学学报》2024年第5期355-358,共4页Journal of Dalian Polytechnic University

基　　金：辽宁省教育厅面上项目(LJKZZ20220060).

摘　　要：D-半乳糖工业化生产过程中会产生大量的母液,母液中仍含有大量的D-半乳糖,对生产母液回收利用,不仅可以提高D-半乳糖成品收率,还可以减少废液排放。D-半乳糖母液成分复杂,颜色呈深褐色,必须经过脱色除杂处理,才能实现回收利用。本实验建立了树脂-活性炭联合脱色法,筛选获得了性能良好的树脂,并优化了脱色条件和树脂再生条件。结果表明,采用HYA-310树脂和ZX-301活性炭联合脱色,在母液pH3.0、总糖质量浓度90g/L、上样液体积流量0.5mL/min时,脱色效果最好,脱色后母液透光率超过90%。将饱和NaCl用于脱色树脂的再生,树脂交换容量恢复率达到91.2%,可循环使用10次以上。采用该工艺,母液中D-半乳糖收率达60%,D-半乳糖成品纯度超过98%。During the industrial production process of D-galactose, a large amount of mother liquor is generated, which contains a large amount of D-galactose. The yield of D-galactose products can be improved by recycling and utilizing the mother liquor, and the discharge of waste liquid can be reduced. The composition of D-galactose mother liquor is complex and the color is dark brown. Decolorization and impurity removal treatment must be undergo to achieve recycling. A resin activated carbon combined decolorization method was established to obtain high-performance resins, and optimize decolorization and resin regeneration conditions. The results showed that the combination of HYA-310 resin and ZX-301 activated carbon had the best decolorization effect in the conditions of mother liquor pH 3.0, total sugar concentration 90 g/L and the volumetric flow rate of sample solution 0.5 mL/min. The transmittance of mother liquor exceeded 90% after decolorization. The regeneration of decolorizing resin using saturated NaCl resulted in a resin exchange capacity recovery rate of 91.2%, which can be reused more than 10 times. The yield of D-galactose in the mother liquor reached 60%, while the purity of the D-galactose product exceeded 98% in the process.

关 键 词：D-半乳糖 母液回收 HYA-310树脂 脱色 再生 

分 类 号：TQ460.9[化学工程—制药化工]