新疆冠状动脉旁路移植术后患者氯吡格雷相关基因CYP2C19的多态性分析  

Gene polymorphism analysis of Clopidogrel related gene CYP2C19 in patients after coronary artery bypass grafting in Xinjiang

作　　者：叶尔买克·唐沙哈尔[1] 阿依别克·乃比[1] 郭永忠[1] Ermek·Tangsakar;Aybek·Nabi;GUO Yongzhong(Heart and Panvascular Diseases Medicine Treatment Center,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,830001,China)

机构地区：[1]新疆维吾尔自治区人民医院心脏及泛血管医学中心,乌鲁木齐830001

出　　处：《临床心血管病杂志》2024年第8期665-668,共4页Journal of Clinical Cardiology

基　　金：新疆维吾尔自治区人民医院院内项目(No:20220102)。

摘　　要：目的分析新疆冠状动脉(冠脉)旁路移植术患者氯吡格雷相关基因CYP2C19的基因多态性分布情况。方法收集2022年5月—2023年12月在新疆维吾尔自治区人民医院心脏及泛血管医学中心行冠脉旁路移植手术的154例患者的全血标本,检测CYP2C19基因的不同基因型。比较汉族与非汉族人群间CYP2C19基因型和氯吡格雷代谢类型的分布情况。结果非汉族患者CYP2C19*17基因多态性CT基因型频率显著高于汉族患者,差异有统计学意义(P<0.001)。快代谢型及超快代谢型仅在非汉族患者中出现,且差异有统计学意义(P=0.00118)。结论新疆冠脉旁路移植手术患者氯吡格雷相关基因CYP2C19的基因多态性在汉族与非汉族人群间存在差异;快代谢型及超快代谢类型仅在非汉族中出现,且明显高于汉族患者。Objective To analyze the genetic polymorphism distribution of Clopidogrel-related gene CYP2C19 in patients undergoing coronary artery transplantation in Xinjiang.Methods The 154 patients who underwent coronary artery transplantation in Xinjiang Uygur Autonomous Region People's Hospital from May 2022 to December 2023 were collected and detected different genotypes of CYP2C19 gene.We compare the distribution of CYP2C19 genotype and Clopidogrel metabolic type between Han and non-Han populations.Results The frequency of CT genotype of CYP2C19*17 gene polymorphism in non-Han patients was significantly higher than that in Han patients,with statistical significance(P<0.001).Fast metabolic type and ultra-fast metabolic type were found in non-Han patients only.Conclusion There are different expression in the Clopidogrel-related gene CYP2C19 in non-Han populations with coronary artery transplantation in Xinjiang.Fast metabolism type and ultra-fast metabolism type are only found in non-Han patients.

关 键 词：冠状动脉移植术 CYP2C19基因 氯吡格雷 基因多态性 民族 

分 类 号：R541.4[医药卫生—心血管疾病]