ICP-MS测定五层共挤输液用膜中6种金属元素的含量  

Determination of 6 Metallic Elements in Five-layer Co-extrusion Film by ICP-MS

作　　者：宋玉琴 袁良杰 SONG Yu-qin;YUAN Liang-jie(Zibo Institute for Food and Drug Control,Zibo 255086,China;School of Clinical Medicine and Basic Medical Science,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250000,China)

机构地区：[1]淄博市食品药品检验研究院,山东淄博255086 [2]山东第一医科大学(山东省医学科学院)临床与基础医学院,山东济南250000

出　　处：《食品与药品》2024年第5期422-426,共5页Food and Drug

摘　　要：目的建立了电感耦合等离子体质谱法测定五层共挤输液用膜中铜、镉、铬、铅、锡、钡6种金属元素的含量测定方法。方法采用ICP-MS法,射频功率为1550 W,等离子体气体流量为15.0 L/min,辅助气体流量为0.8 L/min,载气流量为0.8 L/min,补偿/稀释气体流量为0.8 L/min,雾化室温度为2℃,采样深度为5.0 mm,蠕动泵转速为0.1 r/s,采集模式为He模式,内标法测定。结果6种元素均在0~100 ng/ml浓度范围内线性关系良好,平均回收率为95.3%~106.0%,RSD为0.8%~6.4%,定量限为0.007~0.04 ng/ml。通过与原标准方法含量测定结果进行比较,铜、镉、铅、钡元素两种方法测定结果无显著差异,而铬和锡元素使用ICP-MS方法测定结果是检出,原标准方法测定结果是未检出。结论ICP-MS法准确灵敏、分析速度快,可用于五层共挤输液用膜的质量控制。Objective To establish an ICP-MS method for determination of Cu,Cd,Cr,Pb,Sn and Ba in five-layer co-extrusion film.Methods An ICP-MS method was used.The parameters of experimental conditions were as follows:the RF power was 1550 W,the plasma gas velocity was 15.0 L/min,the auxiliary gas velocity was 0.8 L/min,the carrier gas velocity was 0.8 L/min,the compensatory and diluent gas velocity was 0.8 L/min,the peristaltic pump rate was 0.1 r/s,the atomizing chamber temperature was 2℃,and the sampling depth was 5.0 mm.He mode was adopted for data acquisition,and internal standard method was used for content determination.Results The calibration curves of 6 metallic elements were linear in the concentration ranges of 0-100 ng/ml.The average recoveries were 95.3%-to 106.0%,with RSDs of 0.8%-6.4%.The limits of quantitation were 0.007-0.04 ng/ml.There was no significant difference between the contents of Cu,Cd,Pb and Ba determined by ICP-MS method and the original standard method,and Cr and Sn were detected by ICP-MS method,while not detected by the original standard method.Conclusion The ICP-MS method is accurate,sensitive and fast.It can be used for the quality control of five-layer co-extrusion infusion membrane.

关 键 词：电感耦合等离子体质谱法 五层共挤输液用膜 金属元素 含量测定 

分 类 号：O657.63[理学—分析化学] TQ460.69[理学—化学]