蜂毒肽在类风湿性关节炎领域的研究进展  

Research advances of melittin in the field of rheumatoid arthritis

作　　者：李欣 曾阳俊 汪磊 晁镜茹 廖洪利[1] 苏春丽 LI Xin;ZENG Yangjun;WANG Lei;CHAO Jingru;LIAO Hongli;SU Chunli(School of Pharmacy,Chengdu Medical College,Sichuan Chengdu 610500,China;Municipal Center for Disease Control&Prevention,Sichuan Jianyang 641400,China;School of Public Health,Chengdu Medical College,Sichuan Chengdu 610500,China)

机构地区：[1]成都医学院药学院,四川成都610500 [2]简阳市疾病预防控制中心,四川成都641400 [3]成都医学院公共卫生学院,四川成都610500

出　　处：《中国医院药学杂志》2024年第17期2062-2065,共4页Chinese Journal of Hospital Pharmacy

基　　金：四川省中央引导地方科技发展资金项目(编号:2023ZYD0062);成都市重点研发项目(编号:2022-YF05-01379-SN);成都医学院学科创新团队项目(编号:CMC-XK-2104)。

摘　　要：类风湿性关节炎作为一种高发病率的自身免疫性疾病严重危害着人类健康。目前临床上主要通过控制炎症达到治疗目的,由于常用的治疗药物多存在严重不良反应,需要在治疗期间密切监测,因此开发治疗效果好且不良反应少的抗类风湿性关节炎药物成为一个亟待解决的医学问题。蜂毒肽是蜜蜂毒素的主要活性成分,具有广泛的药理作用,该文从抗炎、免疫调节、镇痛、降低心血管疾病风险和肾脏保护等方面就蜂毒肽在类风湿性关节炎领域的研究进行综述,以期为蜂毒肽用于治疗类风湿性关节炎的临床开发提供参考。As one of common autoimmune diseases,rheumatoid arthritis(RA)seriously endangers human health.Currently its clinical treatment is mainly achieved by controlling inflammation.Due to a high frequency of serious adverse reactions of commonly used therapeutic drugs,close monitoring is required during treatment.Thus it is imperative to develop efficacious anti-RA agents with minimal side effects.As one active component of bee toxin,melittin has a wide range of pharmacological effects.This review summarized the latest researches of melittin from the aspects of anti-inflammatory,immune regulation,analgesia,lowering the risk of cardiovascular disease and renal protection to provide references for a proper development of RA.

关 键 词：蜂毒肽 类风湿性关节炎 炎症 

分 类 号：R965[医药卫生—药理学]