探讨CRRT联合HP治疗MODS合并AKI的疗效及安全性  

Exploring the efficacy and safety of CRRT combined with HP in the treatment of MODS complicated with AKI

作　　者：姚月平 邹晗 姚少峰 姚峰[1] 钱何布 Yao Yueping;Zou Han;Yao Shaofeng;Yao Feng;Qian Hebu(Suzhou University Affiliated Suzhou Ninth Hospital,Suzhou,Jiangsu 215200,China)

机构地区：[1]苏州大学附属苏州九院,江苏苏州215200

出　　处：《首都食品与医药》2024年第19期33-35,共3页Capital Food Medicine

摘　　要：目的探究与分析连续肾脏替代治疗(CRRT)联合血液灌流(HP)治疗多器官功能障碍综合征(MODS)合并急性肾损伤(AKI)的疗效及安全性。方法选取苏州大学附属苏州九院自2022年4月-2024年4月收治的MODS合并AKI患者80例,采取随机数字表法分组,每组各40例,对照组采用CRRT治疗,观察组在其基础上增加HP治疗,对比两组治疗效果。结果观察组治疗后与对照组治疗后相比,HR较低、MBP较高、BUN较低、SCr较低、CO_(2)CP较高,IL-1、IL-6、IL-8及TNF-α值均较低,差异有统计学意义(P<0.05)。结论CRRT联合HP治疗MODS合并AKI可更好地改善患者的心肾功能指标及炎症因子水平,安全性高。Objective To explore and analyze the efficacy and safety of continuous renal replacement therapy(CRRT)combined with hemoperfusion for the treatment of multiple organ dysfunction syndrome(MODS)with acute kidney injury(AKI).Methods Eighty cases of MODS combined with AKI patients admitted to our hospital from April 2022 to April 2024 were selected.They were randomly divided into two groups,with 40 cases in each group.The control group received CRRT treatment,while the observation group received HP treatment in addition to CRRT.The therapeutic effects between the two groups were compared.Results Compared with the control group,after treatment,the observation group showed lower heart rate(HR),higher mean blood pressure(MBP),lower blood urea nitrogen(BUN)and serum creatinine(SCr)levels,higher partial pressure of carbon dioxide(CO_(2)CP),and lower levels of interleukin-1(IL-1),interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-alpha(TNF-α),the differences were statistically significant(P<0.05).Conclusion Combining CRRT with HP treatment for MODS combined with AKI can better promote the improvement of patients’cardiac and renal function indicators,facilitate the improvement of inflammatory cytokine levels,and exhibit high safety.

关 键 词：连续肾脏替代治疗 血液灌注治疗 多器官功能障碍综合征 急性肾损伤 

分 类 号：R692[医药卫生—泌尿科学]