赛必妥联合芬吗通口服预防高危人流患者术后宫腔粘连的效果观察  

Observation of the effect of Saibituo combined with Fenmutong oral administration in preventing postoperative intrauterine adhesions in high-risk abortion patients

作　　者：黄宁[1] 孙星星 李清阳 Huang Ning;Sun Xingxing;Li Qingyang(Hankou Hospital,Wuhan,Hubei 430000,China;Wuhan Economic and Technological Development Zone(Hannan District)People’s Hospital,Wuhan,Hubei 430090,China)

机构地区：[1]武汉市汉口医院,湖北武汉430000 [2]武汉经济技术开发区(汉南区)人民医院,湖北武汉430090

出　　处：《首都食品与医药》2024年第19期55-58,共4页Capital Food Medicine

摘　　要：目的探讨赛必妥联合芬吗通口服预防高危人流患者术后宫腔粘连的效果。方法按照随机数字表法将2020年7月-2021年12月武汉市汉口医院收治的116例高危人流患者分为对照组及观察组。对照组58例进行常规治疗,观察组58例加用赛必妥联合芬吗通口服治疗。比较两组患者术后宫腔粘连和不良反应发生情况,治疗前后白介素-10(IL-10)、白介素-18(IL-18)和血液流变学指标水平。结果治疗后与同组治疗前相比,两组IL-10水平均明显升高,且与对照组相比,观察组明显更高(P<0.05),两组的血浆黏度、全血黏度、IL-18水平均明显降低,且观察组与对照组相比明显更低(P<0.05)。对照组的宫腔粘连率为20.69%,观察组的宫腔粘连率为6.90%,与对照组相比,观察组明显更低(P<0.05)。观察组和对照组的不良反应发生情况无明显差异(P>0.05)。结论芬吗通联合赛必妥对高危人流患者术后宫腔粘连具有显著预防作用,可以有效改善患者血流,且安全性良好。Objective To explore the effect of combination of Saibituo and Fenmutong oral administration in preventing postoperative intrauterine adhesions in high-risk patients undergoing abortion.Methods 116 high-risk abortion patients admitted to our hospital from July 2020 to December 2021 were divided into a control group and an observation group using a random number table method.58 cases in the control group received routine treatment,while 58 cases in the observation group received additional oral treatment with cypermethrin combined with fentanyl.Compare the incidence of postoperative intrauterine adhesions and adverse reactions between two groups of patients,as well as the levels of interleukin-10(IL-10),interleukin-18(IL-18),and hemorheological indicators before and after treatment.Results After treatment,compared with before treatment in the same group,the levels of IL-10 in both groups were significantly increased,and compared with the control group,the observation group was significantly higher(P<0.05).The plasma viscosity,whole blood viscosity,and IL-18 levels in both groups were significantly reduced,and the observation group was significantly lower than the control group(P<0.05).The intrauterine adhesion rate in the control group was 20.69%,while the intrauterine adhesion rate in the observation group was 6.90%.Compared with the control group,the observation group had a significantly lower intrauterine adhesion rate(P<0.05).There was no significant difference in adverse reactions between the observation group and the control group(P>0.05).Conclusion The combination of Fenmutong and Cebitol has a significant preventive effect on postoperative intrauterine adhesions in high-risk abortion patients,which can effectively improve patient blood flow and has good safety.

关 键 词：高危人流 芬吗通 赛必妥 宫腔粘连 血液流变学指标 

分 类 号：R711.74[医药卫生—妇产科学]