吗啉硝唑联合高压氧治疗Wagner 2~4级糖尿病足创面感染的回顾性队列研究  

Morinidazole combined with hyperbaric oxygen therapy in the treatment of Wagner grade 2-4 diabetic foot ulcer infection:a retrospective Cohort study

作　　者：刘扬 牛锋[2] 刘玉娟 俞一 王冬婷 Liu Yang;Niu Feng;Liu Yujuan;Yu Yi;Wang Dongting(Department of Pharmacy,Jinshan Hospital of Fudan University,Shanghai 201508,China;Department of Rehabilitation Medicine,Jinshan Hospital of Fudan University,Shanghai 201508,China;Wound Care and Treatment Center,Jinshan Hospital of Fudan University,Shanghai 201508,China)

机构地区：[1]复旦大学附属金山医院药剂科,上海201508 [2]复旦大学附属金山医院康复医学科,上海201508 [3]复旦大学附属金山医院创面诊疗中心,上海201508

出　　处：《中华航海医学与高气压医学杂志》2024年第4期477-480,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的评价吗啉硝唑联合高压氧对Wagner 2~4级糖尿病足创面感染生物标志物水平的影响及临床疗效。方法回顾性分析2021年1月至2023年11月复旦大学附属金山医院收治的89例Wagner 2~4级糖尿病足患者的临床资料。按照治疗方法的不同,将患者分为观察组(46例)和对照组(43例)。对照组单纯采用吗啉硝唑治疗,观察组采用吗啉硝唑联合高压氧治疗,连续治疗3周后,比较2组治疗前后以及2组间的炎症指标、厌氧菌清除率、临床总有效率以及不良反应发生率。结果治疗前,2组间炎症指标[全血白细胞计数(WBC)、血清C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)]差异均无统计学意义(均P>0.05);治疗后,2组炎症指标均低于治疗前(均P<0.05),且观察组水平均低于对照组(均P<0.05)。治疗后,观察组厌氧菌清除率为95.65%,对照组为74.42%,差异有统计学意义(P<0.05);观察组临床总有效率为97.83%,对照组为81.40%,差异有统计学意义(P<0.05);观察组不良反应发生率为8.70%,对照组为6.98%,差异无统计学意义(P>0.05)。结论吗啉硝唑联合高压氧治疗Wagner 2~4级糖尿病足的效果确切,比单用吗林硝唑药物治疗能更有效地控制糖尿病足创面感染,促进糖尿病足的愈合。ObjectiveTo evaluate the effect of morinidazole combined with hyperbaric oxygen therapy on the levels of infection biomarkers and clinical efficacy of Wagner grades 2–4 diabetic foot ulcer infection.MethodsThe clinical data of 89 selected patients with Wagner grades 2–4 diabetic foot ulcer,hospitalized in our hospital from January 2021 to November 2023,were retrospectively analyzed.The patients were divided into observation group(46 cases)and control group(43 cases)based on different treatment methods.The control group was treated with morinidazole sodium chloride injection only,while the observation group received hyperbaric oxygen therapy additionally.Both groups were treated continuously for 3 weeks,and the levels of inflammatory markers,anaerobic bacteria clearance rate,clinical total effect rate,and incidence of adverse reactions were compared before and after treatment,as well as between the two groups.ResultsThere were no statistically significant difference in inflammatory markers[white blood cell count(WBC),serum C-reactive protein(CRP),procalcitonin(PCT),and interleukin-6(IL-6)]between the two groups before treatment(P>0.05).After 3 weeks of treatment,the levels of inflammatory markers in both groups were significantly decreased than those before treatment(P<0.05),and the levels in the observation group were significantly lower than those in the control group(P<0.05).The anaerobic bacteria clearance rate after treatment was 95.65%in the observation group and 74.42%in the control group,with a statistically significant difference(P<0.05);the clinical total effective rate after treatment was 97.83%in the observation group and 81.40%in the control group,with a statistically significant difference(P<0.05);the incidence of adverse reactions was 8.70%in the observation group and 6.98%in the control group,with no statistically significant difference(P>0.05).ConclusionMorinidazole combined with hyperbaric oxygen therapy is effective in the treatment of Wagner grades 2–4 diabetic foot ulcers,which can more

关 键 词：糖尿病足 高压氧 吗啉硝唑 感染性生物标志物 

分 类 号：R587.2[医药卫生—内分泌]