三甲胺N-氧化物在认知障碍相关疾病中的研究进展  

Research advances of trimethylamine N-oxide in cognitive impairment diseases

作　　者：郭虹妍 李乔 赵玉晶 李青 李岩松 王强[1] Guo Hongyan;Li Qiao;Zhao Yujing;Li Qing;Li Yansong;Wang Qiang(Department of Anesthesiology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院麻醉科,西安710061

出　　处：《国际麻醉学与复苏杂志》2024年第8期875-880,共6页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(82274290)。

摘　　要：三甲胺N-氧化物(TMAO)是一种常见的肠道菌群代谢产物,血浆TMAO水平与中枢认知障碍相关疾病有着较强的相关性,在阿尔茨海默病、帕金森病、老年相关性痴呆、围手术期神经认知障碍等多种疾病中均有升高的趋势,可以作为认知障碍相关疾病的预测因子。文章综述了既往关于TMAO与认知障碍相关疾病的临床研究与基础研究,概括了TMAO在其中发挥作用的可能机制,以期为认知障碍相关疾病的防治提供新的思路与参考。Trimethylamine N-oxide(TMAO)is a metabolite commonly produced by intestinal flora.Elevated levels of TMAO in plasma have been strongly associated with central cognitive impairment-related diseases such as Alzheimer's disease,Parkinson's disease,age-related cognitive decline,and perioperative neurocognitive disorders.TMAO has shown potential as a predictive marker for cognitive impairment-related diseases.This review aims to summarize previous clinical and basic research on TMAO and its connec-tion to cognitive impairment-related diseases.Additionally,it will explore the potential mechanisms through which TMAO influences these diseases,offering new insights and references for the prevention and treatment of cognitive impairment-related diseases.

关 键 词：三甲胺N-氧化物 认知障碍 

分 类 号：R614[医药卫生—麻醉学]