Rhodium(Ⅲ)-catalyzed diastereo-and enantioselective hydrosilylation/cyclization reaction of cyclohexadienone-tetheredα,β-unsaturated aldehydes  

作　　者：Yi-Fan Wang Hao-Yun Yu Hao Xu Ya-Jie Wang Xiaodi Yang Yu-Hui Wang Ping Tian Guo-Qiang Lin 

机构地区：[1]The Research Center of Chiral Drugs,Shanghai Frontiers Science Center for TCM Chemical Biology,Innovation Research Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

出　　处：《Chinese Chemical Letters》2024年第9期160-164,共5页中国化学快报（英文版）

基　　金：financial support from the National Key R&D Program of China(No.2022YFF1202600);the National Natural Science Foundation of China(Nos.22001172,22071155,and22371188);the Science and Technology Commission of Shanghai Municipality(Nos.20XD1403600 and 20400750300);the Shanghai Municipal Education Commission(No.2019-01-07-00-10-E00072);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-202004);the Shanghai Municipal Health Commission/Shanghai Municipal Administration of Traditional Chinese Medicine[No.ZY(2021-2023)-0501];Organizational Key R&D Program of SHUTCM(No.2023YZZ01)。

摘　　要：A rhodium(Ⅲ)-catalyzed hydrosilylation/cyclization reaction of cyclohexadienone-tetheredα,β-unsaturated aldehydes(1,6-dienes)with triethylsilane is described,providing a series of cishydrobenzofurans,cis-hydroindoles,and cishydroindenes bearing silyl enol ether in good to excellent yields and excellent stereoselectivities.Additionally,the versatility of this method was demonstrated through a gram-scale experiment and various downstream transformations,highlighting its utility.

关 键 词：Rhodium(Ⅲ)catalysis Hydrosilylation/cyclization 1 6-Dienes Silyl enol ether Diastereo-and enantioselectivity 

分 类 号：O621.251[理学—有机化学]