Niduenes A-F,six functionalized sesterterpenoids with a pentacyclic 5/5/5/5/6 skeleton from endophytic fungus Aspergillus nidulans  

作　　者：Aimin Fu Chunmei Chen Qin Li Nanjin Ding Jiaxin Dong Yu Chen Mengsha Wei Weiguang Sun Hucheng Zhu Yonghui Zhang 

机构地区：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

出　　处：《Chinese Chemical Letters》2024年第9期202-205,共4页中国化学快报（英文版）

基　　金：financially supported by the National Key Research and Development Program of China(No.2021YFA0910500);the National Natural Science Foundation of China(Nos.U22A20380,82104028,82173706 and 82373755);Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Science and Technology Major Project of Hubei Province(No.2021ACA012);the Fundamental Research Funds for the Central Universities,HUST(No.2021JYCXJJ058)。

摘　　要：Niduenes A-F(1-6),six novel sesterterpenoids with unprecedented 5/5/5/5/6 pentacyclic ring skeleton were isolated from endophytic fungus Aspergillus nidulans.Compounds 1 and 2 represent the first examples of aromatic pentacyclic sesterterpenoids.Their structures and configurations were elucidated by spectroscopic data and single-crystal X-ray diffraction analyses.Compound 4 demonstrated potent resensitization of SW620/AD300 cells to paclitaxel(PTX).Rhodamine 123 accumulation assay and docking analysis further support that 4 inhibitory the efflux function of P-glycoprotein(P-gp).

关 键 词：Aspergillus nidulans Sesterterpenoids Aromatic sesterterpenoids Structure elucidation Single-crystal X-ray diffraction Biosynthetic pathways 

分 类 号：TQ460.1[化学工程—制药化工]