(+)/(-)-Mycosphatide A,a pair of highly oxidized polyketides with lipid-lowering activity from the mangrove endophytic fungus Mycosphaerella sp.SYSU-DZG01  

作　　者：Qi Tan Run-Zhu Fan Wencong Yang Ge Zou Tao Chen Jianying Wu Bo Wang Sheng Yin Zhigang She 

机构地区：[1]School of Chemistry,Sun Yat-sen University,Guangzhou 510006,China [2]School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China

出　　处：《Chinese Chemical Letters》2024年第9期210-213,共4页中国化学快报（英文版）

基　　金：National Natural Science Foundation of China(Nos.U20A2001,81973195,21877133);the Guangdong Marine Economy Development Special Project(Nos.GDNRC[2022]35,GDNRC[2023]39)。

摘　　要：(±)-Mycosphatide A(1a/1b),a pair of highly oxidized enantiomeric polyketides featuring a unique5/5/6/5-fused tetracyclic ring system,were isolated from the mangrove endophytic fungus Mycosphaerella sp.SYSU-DZG01.Their structures were established by extensive spectroscopic analyses,single crystal Xray diffraction,and experimental electronic circular dichroism(ECD)spectra comparison.The plausible biosynthetic pathway of 1 was proposed,which involved the generation of a key spiro[4.5]decane scaffold.Compounds(+)-1a and(-)-1b exhibited significant lipid-lowering activity in 3T3-L1 adipocytes model,with EC50values of 7.85±1.56 and 8.87±0.80μmol/L,respectively.

关 键 词：Mangrove endophytic fungus Mycosphaerella sp. Polyketide Highly oxidized Lipid-lowering activity 

分 类 号：TQ460.1[化学工程—制药化工]