Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide  

作　　者：Gongcheng Ma Qihang Ding Yuding Zhang Yue Wang Jingjing Xiang Mingle Li Qi Zhao Saipeng Huang Ping Gong Jong Seung Kim 

机构地区：[1]Guangdong Key Laboratory of Nanomedicine,Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations,CAS-HK Joint Lab for Biomaterials,Research Laboratory for Biomedical Optics and Molecular Imaging,Shenzhen Key Laboratory for Molecular Imaging,CAS Key Lab for Health Informatics,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Department of Chemistry,Korea University,Seoul 02841,South Korea [4]School of Chemical Engineering,Northwest University,Xi’an 710069,China [5]Cancer Center,Institute of Translational Medicine,Faculty of Health Sciences,University of Macao,Macao 999078,China [6]State Key Laboratory of Fine Chemicals,College of Materials Science and Engineering,Shenzhen University,Shenzhen 518060,China

出　　处：《Chinese Chemical Letters》2024年第9期223-226,共4页中国化学快报（英文版）

基　　金：supported by the National Key R&D Programs(No.2021YFA0910001);the Shenzhen Science and Technology Program(Nos.JCYJ20210324115804013,JCYJ2022081810160716,JCYJ20220531093604009);the Specific Research Assistant Funding Program of Chinese Academy of Sciences(No.E35902);the National Natural Science Foundation of China(Nos.22005343,32000982);the Guangdong Provincial Key Area R&D Program(No.2020B1111540001).

摘　　要：Carbon monoxide(CO)is a vital intracellular gas messenger known for its cytoprotective and homeostatic properties.It plays a pivotal role in a myriad of biological processes.Therefore,the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease diagnosis.We herein introduce NFCOP,a state-of-the-art near-infrared(NIR)turn-on fluorescence(FL)probe that has been meticulously designed for highly sensitive,swift and selective imaging of CO.The NFCOP response occurred rapidly with CO,within just 10 s,and the calculated detection limit for CO was determined to be 0.32μmol/L.Further investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.

关 键 词：Palladium-free Chemoselective probe Fluorescence imaging Carbon monoxide NEAR-INFRARED 

分 类 号：O657.3[理学—分析化学] R313[理学—化学]