Antibacterial performance of cationic quaternary phosphonium-modified chitosan polymer in water  

作　　者：Jinjie Lu Qikai Liu Yuting Zhang Yi Zhou Yanbo Zhou 

机构地区：[1]State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process,East China University of Science and Technology,Shanghai 200237,China

出　　处：《Chinese Chemical Letters》2024年第9期326-330,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.51778230,22376065);Program of Shanghai Outstanding Technology Leaders(No.20XD1433900);the Science and Technology Commission of Shanghai Municipality(No.22ZR1418600);Shanghai Municipal Science and Technology(No.20DZ2250400)。

摘　　要：Microbial contamination in water has emerged as a critical concern and thus developing biocide materials for controlling microbial contamination is crucial.Removing all pathogenic bacteria in water is difficult when using traditional water treatment technologies.Moreover,these bacteria can easily reproduce during pipeline distribution.In this work,a facile and effective chitosan derivative biocide denoted as PCC was developed by grafting with quaternary phosphonium salt(QPS).PCC became positively charged with a wide range of p H and demonstrated antibacterial activity up to 95%and 100%against Escherichia coli and Staphylococcus aureus as model pathogens,respectively.The grafting of QPS may disrupt the cell membrane and lead to bacterial inactivation,as demonstrated by the scanning electron microscopy image and the concentration of intracellular substance leakage.MTT assay results indicate that PCC achieved good biocompatibility with negligible in vitro cytotoxicity.These findings introduce a promising approach for bacterial decontamination due to its low cytotoxicity and high biocidal activity.

关 键 词：CHITOSAN Quaternary phosphonium salt Antibacterial performance Antibacterial mechanism Morphology change 

分 类 号：TQ317[化学工程—高聚物工业] X703[环境科学与工程—环境工程]