苯扎氯铵致颗粒状角化不全2例及文献回顾  

Granular parakeratosis caused by benzalkonium chloride:A report of two cases and literature review

作　　者：龙璇 周文玉 杨雪婷 姚南 郭子瑜 张桂英[1] 杨苗 廖洁月[1] LONG Xuan;ZHOU Wenyu;YANG Xueting;YAO Nan;GUO Ziyu;ZHANG Guiying;YANG Miao;LIAO Jieyue(Department of Dermatology,the Second Xiangya Hospital of Central South University,Changsha 410000,China)

机构地区：[1]中南大学湘雅二医院皮肤科,长沙410000

出　　处：《实用皮肤病学杂志》2024年第4期253-256,共4页Journal of Practical Dermatology

摘　　要：报道2例由衣物消毒剂致颗粒状角化不全。2例患者在起病前均有使用含苯扎氯铵(benzalkonium chloride)消毒剂史。临床表现为皮肤褶皱部位的棕红色斑疹及色素沉着。组织病理检查均显示角化过度伴颗粒状角化不全,角层内可见嗜碱性颗粒。外用糖皮质激素制剂、口服抗组胺药物效果不佳。嘱患者停用消毒剂后约1个月皮损均得到了明显改善,皮损大部分消退。现报道2例颗粒状角化不全患者并进行文献回顾分析。Two cases of granular parakeratosis caused by clothing disinfectants were reported in this article.Both patients had a history of using benzalkonium chloride disinfectants prior to onset.Clinical manifestations included erythematous patches and hyperpigmentation in skin folds.Histopathological examination revealed hyperkeratosis with granular parakeratosis and presence of basophilic granules within the stratum corneum.Topical corticosteroid creams and oral antihistamines showed poor efficacy.Improvement was noted in skin lesions approximately one month after discontinuation of the disinfectants,with most lesions resolving.This paper reported on two cases of granular parakeratosis,accompanied by a literature review.

关 键 词：颗粒状角化不全 苯扎氯铵 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]