基于刺激响应型聚合物纳米载体的铂类药物递送系统  

Stimulus-responsive Polymeric Nanocarriers for Platinum Drug Delivery

作　　者：陆广林 金园庭 刘祥瑞[2,3,4] 黄楚娟 LU Guang-lin;JIN Yuan-ting;LIU Xiang-rui;HUANG Chu-juan(School of Life Sciences,China Jiliang University,Hangzhou 310018,China;Center for Medical Research and Innovation in Digestive System Tumors,Ministry of Education,Hangzhou 310020,China;Department of Gastroenterology,Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China;Innovation Center of Yangtze River Delta,Zhejiang University,Jiaxing 314102,China)

机构地区：[1]中国计量大学生命科学学院,杭州310018 [2]教育部消化系统肿瘤医药基础研究创新中心,杭州310020 [3]浙江大学医学院第二附属医院消化内科,杭州310009 [4]浙江大学长三角智慧绿洲创新中心,嘉兴314102

出　　处：《高分子通报》2024年第10期1317-1336,共20页Polymer Bulletin

摘　　要：铂类药物因其独特的作用机制,具有高效、抗癌范围广等优点,是临床上最为常见的化疗用药。但是,铂类药物所带来的毒副作用和频发的耐药性限制了其治疗效果。随着纳米技术的发展,利用纳米载体实现其靶向递送成为了近年来的研究热点。在不同纳米载体中,对刺激响应型聚合物纳米载体的开发成为现阶段构建铂类药物递送系统的趋势。一方面,基于聚合物的纳米递送系统,能够利用聚合物链段,提高药物负载量,实现铂类药物的联用。另一方面,也能够通过刺激响应,利用肿瘤微环境,实现铂类药物在肿瘤部位的精准递送与蓄积渗透。本文在介绍铂类药物的基础上,根据刺激响应的来源分类,综述了近年来不同刺激响应型聚合物纳米载体在高效递送铂类药物上的研究进展,重点分析了聚合物纳米载体的设计策略与控释机理,旨在为开发针对铂类药物临床适用的聚合物纳米递送系统提供思路和理论参考。Platinum(Pt)drugs are the most common chemotherapeutic agents in the clinic due to their unique anticancer mechanism,which endows them with high efficiency and broad-spectrum resistance to tumors.However,the toxicity and side effects induced by Pt drugs,also,the drug resistance limits the therapeutic effects of Pt drugs.With the development of nanotechnology,the use of nanocarriers to realize the targeted delivery of Pt drugs has become a hot research topic in recent years.Among the various kinds of nanocarriers,the development of stimuli-responsive polymeric nanocarriers has become a trend in the construction of Pt drug delivery systems at this stage.On the one hand,polymer-based nano-delivery system is capable of taking advantage of polymer segments to enhance loading capacity and achieve the conjugation of different drugs.On the other hand,it is capable of utilizing the tumor microenvironment to achieve the precise delivery and accumulation and penetration of Pt drugs through stimulation response.According to the classification of stimuli-responsive sources,this review overviews the recent progress of different stimuli-responsive polymeric nanocarriers to deliver Pt drugs efficiently,following the introduction of platinum drugs.The design strategy and the controlled-release mechanism of polymeric nanocarriers are analyzed with emphasis.This review aims to provide the research and development(R&D)idea and theoretical support for a clinically applicable polymer-based nano-delivery system for Pt drugs.

关 键 词：铂类药物 聚合物 纳米递送系统 刺激响应 

分 类 号：TQ460.4[化学工程—制药化工] TB383.1[一般工业技术—材料科学与工程]