天然高分子抗菌水凝胶伤口敷料研究进展  

Research Progress on Natural Polymer Antibacterial Hydrogel Wound Dressings

作　　者：张广明 王保平 程萍 范治平 韩军 ZHANG Guang-ming;WANG Bao-ping;CHENG Ping;FAN Zhi-ping;HAN Jun(Institute of BioPharmaceutical Research,Liaocheng University,Liaocheng 252059,China;Liaocheng High-Tech Biotechnology Co.,Ltd,Liaocheng 252059,China)

机构地区：[1]聊城大学生物制药研究院,聊城252059 [2]聊城高新生物技术有限公司,聊城252059

出　　处：《高分子通报》2024年第10期1337-1353,共17页Polymer Bulletin

基　　金：国家“重大新药创制”科技重大专项项目(项目号2017ZX09201003-013);山东省自然科学基金(基金号ZR-2021ME127,ZR2016EL04);聊城大学博士基金(基金号318051609);山东省泰山学者研究基金(基金号319190201)资助项目。

摘　　要：天然高分子包括多糖和蛋白质等,其来源广泛且具有丰富的功能基团、易于改性,部分天然高分子还兼具抗菌性能和独特生物学性能,这些特点使其在制备抗菌水凝胶敷料中颇具优势。天然高分子水凝胶通常具有良好的生物相容性、可降解性和亲水性等,其三维结构为抗菌物质提供了理想的负载空间。对于抗菌水凝胶敷料的制备,除了材料的选择,交联策略的设计也至关重要。本文详细汇总了近年来天然高分子抗菌水凝胶敷料的制备方法,包括化学交联、物理交联以及杂化交联等;并且根据抗菌性能的来源,将其分为固有抗菌性能的天然高分子水凝胶和负载抗菌物质的天然高分子水凝胶,进而对这两种水凝胶敷料在医疗、健康等领域的应用进行了详细阐述;最后,对天然高分子抗菌水凝胶现存研究瓶颈进行分析并对其未来发展机遇进行展望。Natural polymers,such as polysaccharides and proteins,are abundant in nature,boasting abundent functional groups that lend themselves readily to modify.Some natural polymers also exhibit inherent antibacterial properties,alongside unique biological attributes.Hydrogels derived from natural polymers typically demonstrate excellent biocompatibility,degradability,and hydrophilicity,owing to their three-dimensional structure which provides an ideal reservoir for antibacterial agents.These attributes confer a distinct advantage upon natural polymers in the formulation of antibacterial hydrogel dressings.Beyond material selection,the choice of crosslinking strategy is pivotal.This work summarizes recent methodologies for the preparation of natural polymer antibacterial hydrogel dressings,encompassing chemical,physical,and hybrid crosslinking techniques.Based on their antibacterial attributes,hydrogels are categorized into two classes:those with inherent antibacterial properties and those laden with antibacterial agents.Detailed accounts are provided regarding the application and potential of these hydrogel dressings in medical,healthcare,and allied domains.Lastly,the extant research bottlenecks are analyzed and the future development for natural polymer antibacterial hydrogels is prospected.

关 键 词：天然高分子 抗菌水凝胶 伤口敷料 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]