一起幼儿园人腺病毒感染暴发疫情流行病学调查  

Epidemiological investigation of a human adenovirus infection outbreak in a kindergarten

作　　者：谢赐福 熊姿[1] 宋丽新[1] 尹鹏亮 XIE Cifu;XIONG Zi;SONG Lixin;YIN Pengliang(Department of Tuberculosis Control and Prevention,Changsha Center for Disease Control and Prevention,Changsha,Hunan 410004,China)

机构地区：[1]长沙市疾病预防控制中心结核病防治科,湖南长沙410004

出　　处：《预防医学》2024年第10期889-892,共4页China Preventive Medicine Journal

摘　　要：2022年5月30日,长沙市疾病预防控制中心接到报告,某幼儿园出现多例发热病例,立即开展现场流行病学调查、实验室检测和处置工作。共报告76例病例,均为学生,罹患率为9.93%。发病时间集中在5月18日—6月8日。主要临床症状为发热、咳嗽和咽痛,均为轻症。检出人腺病毒(HAdV)核酸阳性或抗原阳性39份,对其中7份核酸阳性标本进行病毒分离培养和基因型别鉴定,结果均为HAdV-7型。根据现场流行病学调查和实验室检测结果判断这是一起由HAdV-7型感染引起的暴发疫情。疫情扩散的主要原因可能为幼儿园发现疫情后未及时报告,也与幼儿园学生密集、教室通风不良、晨午检工作不严、日常消毒不规范和所在社区存在HAdV疫情流行有关。幼儿园应完善传染病防控机制、严格遵守疫情报告规定、落实三早措施、规范消毒工作、加强日常通风,避免发生类似疫情。On May 302022,Changsha Center for Disease Control and Prevention received a report of multiple cases of fever from a kindergarten.A field epidemiology investigation,laboratory testing,and control and prevention work were immediately conducted.A total of 76 cases were reported,and all were students,with an attack rate of 9.93%.The on⁃set of illness was peaked between May 18 and June 8.The main clinical symptoms were fever,cough and sore throat,and all the cases were mild.There were 39 cases tested positive for human adenovirus(HAdV)nucleic acid or antigen,and 7 nucleic acid positive specimens were identified as HAdV-7 through virus isolation,culture and genotyping.The field epidemiology investigation and laboratory testing results concluded that it was a clustered outbreak caused by HAdV-7 infection.The main reason for the spread of the outbreak might be that the kindergarten failed to report it in time.High student density,poor classroom ventilation,lax morning and afternoon inspections,non-standard daily disin⁃fection,and the prevalence of HAdV outbreaks in the community were also associated.Kindergartens should improve its infectious disease prevention and control mechanism,strictly follow the reporting regulations,implement the three early measures,standardize disinfection work,and enhance daily ventilation to avoid similar outbreaks in the future.

关 键 词：人腺病毒 暴发疫情 幼儿园 流行病学调查 

分 类 号：R181.3[医药卫生—流行病学] R511.8[医药卫生—公共卫生与预防医学]