中药有效成分及其复方防治非酒精性脂肪性肝病的现状与展望  

Active components of traditional Chinese medicine and their compound prescriptions in prevention and treatment of nonalcoholic fatty liver disease:Current status and prospects

作　　者：潘雨晴 毛傲洁 于楚楚 胡义扬[1] PAN Yuqing;MAO Aojie;YU Chuchu;HU Yiyang(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Institute of Liver Diseases,Shanghai University of Traditional Chinese,Key Laboratory of Liver and Kidney Diseases of the Ministry of Education,Shanghai University of Traditional Chinese Medicine,Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海中医药大学肝病研究所,上海中医药大学教育部肝肾疾病重点实验室,上海市中医临床重点实验室,上海201203

出　　处：《临床肝胆病杂志》2024年第10期1933-1941,共9页Journal of Clinical Hepatology

基　　金：国家自然科学基金面上项目(82174186)。

摘　　要：非酒精性脂肪性肝病(NAFLD)是目前全球患病率最高的慢性肝病,发病机制复杂,临床治疗手段局限。近20多年来,从中药中发现治疗NAFLD的有效成分以及能发挥多靶点综合作用的成分复方是研究热点之一。本文根据其化学成分,以黄酮类、酚类、萜类、生物碱类、皂苷类分类阐述具有治疗NAFLD前景的中药有效成分,以及具有配伍增效作用的有效成分复方,以期进一步为NAFLD药物治疗策略提供新思路。Nonalcoholic fatty liver disease(NAFLD)is currently a chronic liver disease with the highest prevalence rate in the world,with complex pathogeneses and limited clinical treatment methods.Over the past 20 years,the discovery of active components for NAFLD treatment from traditional Chinese medicine and compound prescriptions of the components that can exert a multi-target effect has been one of the research hotspots.Based on the chemical components of traditional Chinese medicine,this article elaborates on the active components with a promising future in the treatment of NAFLD,including flavonoids,phenols,terpenoids,alkaloids,and saponins,as well as the compound prescriptions of active components with a synergistic effect,in order to provide new ideas for the strategies of pharmacotherapy for NAFLD.

关 键 词：非酒精性脂肪性肝病 中药 复方配伍 

分 类 号：R259[医药卫生—中西医结合]