Building the toolbox for in vivo glia-to-neuron reprogramming  

作　　者：Ye Xie Bo Chen 

机构地区：[1]Departments of Ophthalmology and Neuroscience,Icahn School of Medicine at Mount Sinai,New York,NY,USA

出　　处：《Neural Regeneration Research》2024年第6期1171-1172,共2页中国神经再生研究（英文版）

基　　金：supported by National Institutes of Health grants R01 EY024986 and R01 EY028921,an unrestricted challenge grant from Research to Prevent Blindness;the New York Eye and Ear Infirmary Foundation;The Harold W.McGraw,Jr.Family Foundation for Vision Research(to BC)。

摘　　要：Unlike regenerative-competent species that possess a remarkable intrinsic capacity to replenish lost neurons and restore neurocircuits spontaneously,the central nervous system in adult mammals lacks the ability to compensate for the neuronal loss caused by neurodegenerative diseases or traumatic injuries resulting in permanent loss of functionality.Inspired by earlier discoveries that radial glia or astrocytes isolated from the postnatal cortex can generate neurons.

关 键 词：INJURIES CORTEX diseases 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]