有机硒化合物荧光探针研究进展  

Recent Progress in Fluorescent Probe for Organoselenium Compounds

作　　者：张继东 杨垚 薛凯茜 丁美娟 夏曾润 ZHANG Ji-dong;YANG Yao;XUE Kai-xi;DING Mei-juan;XIA Zeng-run(Interfacial Porous Materials Key Laboratory of Higher Education in Shaanxi Province,School of Chemistry and Environmental,Ankang Univerisity,Ankang 725000,China;Key Laboratory of Se-Enriched Products Development and Quality Control of Ministry of Agriculture,Se-Enriched Products Research Institute of China,Ankang 725000,China)

机构地区：[1]安康学院化学与环境学院界面多孔材料陕西省高等学校重点实验室,陕西安康725000 [2]中国富硒产业研究院农业农村部富硒产品开发与质量控制重点实验室,陕西安康725000

出　　处：《化学试剂》2024年第10期35-43,共9页Chemical Reagents

基　　金：陕西省技术创新引导专项基金项目(2022QFY09-09);陕西省重点研发计划项目(2023YBGY-152);陕西省教育厅专项科研计划项目(23JK0274);安康市科学技术研究发展计划项目(AK2022-GY-02)。

摘　　要：荧光探针不仅可以识别目标分析物,而且可以通过荧光信号变化实现定量检测。近年来,含硒有机化合物作为荧光探针已广泛用于检测各种分析物。如金属阳离子和阴离子荧光检测、细胞成像和生物活性监测等。含硒荧光探针与含N-、O-、和S-的荧光探针相比较具有特定优势,其具有高的反应活性,包括氧化、消除以及与亲核试剂和亲电试剂的反应等。此外,含硒的化合物表现出低的氧化还原电位,根据这一性能开发出一系列特定功能的荧光探针,综述了含硒化合物对金属离子、硫醇(RSH)、活性氧物质(ROS)荧光探针的研究进展,并对该领域的发展前景进行了展望。Fluorescence probe can not only identify the target analytes,but also realize quantitative detection through the change of fluorescence signal.In recent years,selenium-containing organic compounds have been used as fluorescent probes to detect various analytes.Selenium-containing organic compounds can be used for metal cation and anion fluorescence detection,cell imaging and bioactivity monitoring.Fluorescence probes containing selenium have specific advantages over fluorescence probes containing N-,O-,and S-,and have as high reactivity,including oxidation,elimination,and reactions with nucleophiles and electrophiles.In addition,selenium-containing compounds exhibit low redox potential,and a series of fluorescence probes with specific functions have been developed based on this property.The research progress of selenium-containing compounds on the fluorescence probes of metal ions,thiols(RSH)and reactive oxygen species(ROS)was reviewed,and the development prospect in this field was prospected.

关 键 词：有机硒化合物 荧光探针 金属离子 硫醇 过氧化氢 次氯酸 

分 类 号：O65[理学—分析化学]