Infection with Listeria monocytogenes meningoencephalitis:A case report  

作　　者：Da-Zhen Xu Quan-Hui Tan 

机构地区：[1]Department of Nursing,Shanghai Sixth People’s Hospital,Shanghai 200233,China [2]Department of Infectious Disease,Shanghai Sixth People’s Hospital,Shanghai 200233,China

出　　处：《World Journal of Clinical Cases》2024年第33期6629-6634,共6页世界临床病例杂志（英文）

基　　金：Supported by National Natural Science Foundation of China,No.82100631.

摘　　要：BACKGROUND Listeria meningitis is an infectious disease of the central nervous system caused by Listeria monocytogenes.This bacterium is widely present in the natural environment and can be transmitted through channels such as food and water.Patients usually show symptoms such as fever,headache,and neck stiffness.In severe cases,coma,convulsions,or even death may occur.Traditional diagnostic methods,such as cerebrospinal fluid(CSF)culture and serological tests,have certain limitations.Although CSF culture is the“gold standard”for diagnosis,it is time-consuming and has a relatively low positivity rate.Serological detection may also result in false positive or false negative results.The emergence of metagenomic sequencing(mNGS)technology has led to a significant break-through in diagnosing Listeria meningitis,allowing quick and accurate detection of various pathogens in samples.CASE SUMMARY Here,we present the case of a previously healthy 64-year-old woman diagnosed with Listeria meningitis using mNGS.She was successfully treated with intravenous ampicillin and meropenem,without any complications.CONCLUSION Listeria meningitis must be considered,especially in patients who fail to show improvement with first-line antibiotic treatments.mNGS significantly reduces the diagnosis time,supporting timely treatment of patients.

关 键 词：Listeria monocytogenes MENINGITIS DIAGNOSIS Treatment Immune function Case report 

分 类 号：R512.1[医药卫生—内科学]