Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications  

作　　者：Ming-Wei Fan Jin-Lan Tian Tan Chen Can Zhang Xin-Ru Liu Zi-Jian Zhao Shu-Hui Zhang Yan Chen 

机构地区：[1]Department of Gastroenterology,Binzhou Medical University Hospital,Binzhou 256600,Shandong Province,China

出　　处：《World Journal of Diabetes》2024年第10期2041-2057,共17页世界糖尿病杂志（英文）

基　　金：Supported by the Natural Science Foundation of Shandong Province,No.ZR2022MH153;“Clinical+X”Project Fund of Binzhou Medical College,No.BY2021LCX11.

摘　　要：Diabetes mellitus(DM)is one of the major causes of mortality worldwide,with inflammation being an important factor in its onset and development.This review summarizes the specific mechanisms of the cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)-stimulator of interferon genes(STING)pathway in mediating inflammatory responses.Furthermore,it compre-hensively presents related research progress and the subsequent involvement of this pathway in the pathogenesis of early-stage DM,diabetic gastroenteropathy,diabetic cardiomyopathy,non-alcoholic fatty liver disease,and other complic-ations.Additionally,the role of cGAS-STING in autonomic dysfunction and intes-tinal dysregulation,which can lead to digestive complications,has been discuss-ed.Altogether,this study provides a comprehensive analysis of the research advances regarding the cGAS-STING pathway-targeted therapeutic agents and the prospects for their application in the precision treatment of DM.

关 键 词：Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes Diabetes mellitus Inflammation Glycolipid metabolism Diabetes gastroenteropathy Nonalcoholic fatty liver disease Diabetes cardiovascular disease Diabetes nephropathy 

分 类 号：R587.1[医药卫生—内分泌]