Chirality discerning and monitoring in a metal cladding optofluidic chip  

作　　者：Qiheng Wei Xueqian Wang Hongrui Shan Yi Lai He Li Hailang Dai Xianfeng Chen 魏麒恒;王雪茜;单洪瑞;来益;李鹤;戴海浪;陈险峰(State Key Laboratory of Advanced Optical Communication Systems and Networks,School of Physics and Astronomy,Shanghai Jiao Tong University,Shanghai 200240,China;State Key Laboratory of Metal Matrix Composites,Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,School of Materials Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China;Department of Head and Neck Surgery and Department of Traditional Chinese Medicine,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China;Collaborative Innovation Center of Light Manipulations and Applications,Shandong Normal University,Jinan 250358,China)

机构地区：[1]State Key Laboratory of Advanced Optical Communication Systems and Networks,School of Physics and Astronomy,Shanghai Jiao Tong University,Shanghai 200240,China [2]State Key Laboratory of Metal Matrix Composites,Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs,School of Materials Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China [3]Department of Head and Neck Surgery and Department of Traditional Chinese Medicine,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China [4]Collaborative Innovation Center of Light Manipulations and Applications,Shandong Normal University,Jinan 250358,China

出　　处：《Chinese Optics Letters》2024年第8期52-57,共6页中国光学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(NSFC)(Nos.12104298 and 12192252);the Shanghai Municipal Science and Technology Major Project(No.2019SHZDZX01-06);the Natural Science Foundation of Shanghai(No.23ZR1428400)。

摘　　要：The metabolic process of chiral drugs plays a significant role in clinics and in research on drugs.Here,we experimentally demonstrate by all-optical means that the chiral molecules can be quickly discriminated and monitored with the ultrahighorder modes excited in a metal cladding optofluidic chip,achieving over 5 times sensitivity with a low-dosage sample.We show that the varying concentration of the chiral drugs can be monitored both in cell and animal experiments,presenting a significant difference between chiral enantiomers at the optimal function time and the effect of the reaction.To our knowledge,this approach provides a new way to achieve important chiral discrimination for the pharmacokinetics and the pharmacodynamics and may present opportunities in indicating the health status of humans.

关 键 词：chiral detection ultrahigh-order guided modes metal cladding optofluidic chip high sensitivity circularly polarized light 

分 类 号：TN492[电子电信—微电子学与固体电子学] R318[医药卫生—生物医学工程]