Quantifying trapping stability of optical tweezers with an external flow  

作　　者：FENG XU YARONG YU YANG LIU YAO CHANG WENXIANG JIAO LIN WANG HOPUI HO BEI WU FEI XU YANQING LU YUANJIE PANG GUANGHUI WANG 

机构地区：[1]College of Engineering and Applied Sciences,Nanjing University,Nanjing 210093,China [2]Key Laboratory of Intelligent Optical Sensing and Integration of the Ministry of Education,Nanjing University,Nanjing 210093,China [3]School of Optical and Electronic Information,Wuhan National Laboratory of Optoelectronics,Huazhong University of Science and Technology,Wuhan 430074,China [4]Department of Biomedical Engineering,The Chinese University of Hong Kong,Hong Kong 999077,China

出　　处：《Photonics Research》2024年第8期1741-1749,共9页光子学研究（英文版）

基　　金：National Natural Science Foundation of China(11874164,61535005,61875083,62375121);Social Development Project of Jiangsu Province(BE2019761);Key Technology Research and Development Program of Shandong Province(2020CXGC011304);Innovation Fund of Wuhan National Laboratory for Optoelectronics;1000Talent Youth Program;General Research Fund from Research Grants Council of HKSAR(14207920,14210517)。

摘　　要：Optical tweezers(OTs)can immobilize and manipulate objects with sizes that span between nano-and micrometer scales.The manipulating ability of OTs is traditionally characterized by stability factor(S),which can only indicate an empirical“hit-or-miss”process.Additionally,the current quantitative models for trapping stability rarely consider the influence of external flow.In this paper,a comprehensive analysis to quantify the optical trapping stability in a perturbed asymmetric potential well is presented from the perspective of statistics,especially for weak trapping scenarios.Our analytical formulation takes experimentally measurable parameters including particle size,optical power,and spot width as inputs and precisely outputs a statistically relevant mean trapping time.Importantly,this formulation takes into account general and realistic cases including fluidic flow velocity and other perturbations.To verify the model,a back-focal-plane-interferometer-monitored trapping experiment in a flow is set up and the statistical characteristics of trapping time demonstrate good agreement with theoretical predictions.In total,the model quantitatively reveals the effects of external disturbance on trapping time,which will find applications where optical trapping stability is challenged by external perturbations in weak trapping conditions.

关 键 词：PROCESS FLOW TRAPPING 

分 类 号：O439[机械工程—光学工程]