肠道微生物及其代谢产物调节胃肠动力的研究进展  

Progress on the regulation of gastrointestinal motility by gut microbiota and their metabolites

作　　者：阳情姚 黄永坤[1] Yang Qingyao;Huang Yongkun(Department of Pediatrics,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院儿科,650032

出　　处：《国际儿科学杂志》2024年第8期508-512,共5页International Journal of Pediatrics

基　　金：国家自然科学基金(81960102)。

摘　　要：在人体的胃肠道中存在着最大、最复杂的微生物群体, 其能够不断适应宿主环境, 并为宿主提供多种关键功能。目前研究发现多种疾病与胃肠动力障碍息息相关, 包括腹泻、便秘、肠易激综合征等。越来越多的证据表明, 肠道微生物及其代谢产物能够影响胃肠动力, 进而影响疾病的发生发展, 它们之间的关系已成为研究的热点。该文综述了肠道微生物及其代谢产物以及益生菌在调节胃肠动力中的作用机制, 以期为开展依赖肠道微生物群的治疗方法来改善胃肠动力提供有价值的线索。There are the largest and most complex microbial groups in the human gastrointestinal tract,which constantly adapt to the host environment and provide multiple key functions for the host.Currently,many diseases are closely related to gastrointestinal motility disorders,including diarrhea,constipation,irritable bowel syndrome and so on.Increasing evidence indicates that the gut microbiota and their metabolites are able to influence gastrointestinal motility,which subsequently influences the development of diseases,and the relationship between them has become a research topic.This article reviews the mechanisms of gut microbiota and their metabolites as well as the mechanisms of probiotics in regulating gastrointestinal motility,in an attempt to provide valuable clues for developing therapies that rely on gut microbiota to improve gastrointestinal motility.

关 键 词：肠道微生物 胃肠动力 肠神经系统 肠道平滑肌 代谢产物 

分 类 号：R725.7[医药卫生—儿科]