母孕期环境风险因素与儿童过敏性疾病关系的研究进展  

Progress on the relationship between environmental risk factors during maternal pregnancy and childhood allergic diseases

作　　者：章银花 于艳艳 Zhang Yinhua;Yu Yanyan(Suzhou Hospital Affiliated to Nanjing Medical University,Suzhou 215002,China)

机构地区：[1]南京医科大学附属苏州医院,215002

出　　处：《国际儿科学杂志》2024年第8期537-542,共6页International Journal of Pediatrics

基　　金：江苏省卫健委妇幼保健科研项目(F202329)。

摘　　要：过敏性疾病是儿童期较常见的慢性非传染性疾病之一, 其发生主要是遗传和环境因素共同作用的结果。有证据表明, 母孕期暴露的风险因素会通过胎盘作用于胎儿, 诱导子代体内免疫失衡、肠道菌群紊乱等, 从而导致儿童过敏性疾病的发生。因此, 母孕期可能是预防儿童过敏性疾病发生的关键时期。该文从母孕期饮食、药物使用、母孕期疾病、过敏原暴露等方面阐述母孕期环境风险因素对儿童过敏性疾病影响的研究进展, 以期为预防儿童过敏性疾病提供新策略。Allergic diseases are one of the most common chronic non-infectious diseases in childhood,primarily resulting from genetic and environmental interactions.Evidence suggests that maternal exposure to risk factors during pregnancy can impact the fetus through the placenta,leading to immune dysregulation,disruptions in gut microbiota composition,and ultimately contributing to the development of allergic diseases in children.Therefore,maternal pregnancy represents a critical period for preventing allergic diseases in children.This article provides an overview of research advancements regarding the influence of environmental risk factors during pregnancy on allergic diseases in children,focusing on aspects such as maternal diet,medication usage,maternal illnesses during pregnancy,and allergen exposure,so as to provide new strategies for preventing childhood allergic diseases.

关 键 词：儿童 母孕期 环境风险因素 过敏性疾病 

分 类 号：R725.9[医药卫生—儿科]