外泌体微小RNA调控骨质疏松骨代谢过程作用的研究进展  

Research progress on the role of exosomal microRNAs in regulating bone metabolism in osteoporosis

作　　者：丁豪(综述) 卜宪敏[2] 吴彬(审校)[3] DING Hao;BU Xianmin;WU Bin(Department of Orthopedics,Caoxian People′s Hospital,Caoxian 274400,China;Pathology Department of Jining First People′s Hospital,Jining 272011,China;Department of Orthopedics,Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]曹县人民医院骨科,曹县274400 [2]济宁市第一人民医院病理科,济宁272011 [3]济宁医学院附属医院骨科,济宁272029

出　　处：《济宁医学院学报》2024年第5期431-434,共4页Journal of Jining Medical University

基　　金：济宁医学院高层次科研项目培育计划(JYGC2021FKJ016);济宁市重点研发计划项目(2021YXNS029,2022YXNS129);济宁医学院附属医院“主诊医师团队专项临床研究计划”项目(ZZTDMS-2023-04)。

摘　　要：骨质疏松症(OP)是常见的骨代谢疾病,由多种因素作用所致。随着研究的不断深入,外泌体微小RNA(miRNA)在OP骨代谢过程中发挥调控作用的分子机制被不断发掘,外泌体miRNA通过影响骨髓间充质干细胞、成骨细胞、破骨细胞的生物学活性,并参与骨代谢、血管生成过程及骨免疫过程来调控OP骨代谢,且在OP的诊疗过程中具备极其重要的应用价值。本文就外泌体miRNA参与调控OP骨代谢进程中作用的研究进展做综述,为OP的治疗提供新的研究思路。Osteoporosis(OP)is a common bone metabolism disease,which is caused by a variety of factors.With the deepening of research,the molecular mechanism of exosomal microRNAs(miRNAs)in OP bone metabolism has been continuously explored,and exosomal miRNAs regulate OP bone metabolism by affecting the biological activities of bone marrow mesenchymal stem cells,osteoblasts and osteoclasts,as well as by participating in the processes of bone metabolism,angiogenesis,and bone immunity,and have an extremely important application value in the diagnostic and therapeutic processes of OP.Therefore,this paper summarizes the research progress on the role of exosomal miRNAs in the regulation of OP bone metabolism,in an attempt to provide new research approaches for the treatment of OP.

关 键 词：骨质疏松骨代谢 外泌体微小RNA 骨髓间充质干细胞 成骨细胞 破骨细胞 血管生成 

分 类 号：R602[医药卫生—外科学]