北京市丰台区无症状儿童致腹泻病毒感染情况调查  

Investigation of Diarrhea Related Virus Infection in Asymptomatic Children in Fengtai District,Beijing,China

作　　者：杨霄星[1] 尉秀霞 武庆锐 秦萌[1] 董晓根 严寒秋[4] 高志勇[4] YANG Xiaoxing;WEI Xiuxia;WU Qingrui;QIN Meng;DONG Xiaogen;YAN Hanqiu;GAO Zhiyong(Fengtai Center for Disease Control and Prevention,Beijing 100070,China;Beijing Economic-Technological Development Area Center for Disease Prevention and Control,Beijing 100006,China;Fangzhuang Community Health Service Center,Beijing 100078,China;Beijing Municipal Center for Disease Prevention and Control,Beijing100013,China)

机构地区：[1]北京市丰台区疾病预防控制中心,北京100070 [2]北京市经济技术开发区疾病预防控制中心,北京100006 [3]方庄社区卫生服务中心,北京100078 [4]北京市疾病预防控制中心,北京100013

出　　处：《病毒学报》2024年第5期1088-1092,共5页Chinese Journal of Virology

基　　金：丰台区卫生计生系统科学研究项目(项目号:2019-128),题目:北京市丰台区3-12岁儿童诺如病毒隐性感染状况调查。

摘　　要：无症状托幼儿童和低学龄儿童中致腹泻病毒感染情况研究较少,本研究抽取三个街镇460名4周之内未出现过急性胃肠炎症状的3~9岁儿童,采集粪便标本,使用实时荧光RT-PCR检测方法对五种致腹泻的病毒(诺如病毒、札如病毒、腺病毒、星状病毒、轮状病毒)进行筛查。无症状儿童中致腹泻病毒检出率为8.26%(38/460),诺如病毒检出率最高为3.26%(15/460),其次为腺病毒(2.61%,12/460),札如病毒(1.52%,7/460),星状病毒(0.43%,2/460),混合检出率为0.43%(2/460),未检测到轮状病毒。不同性别、机构的检出率均无统计学(χ^(2)=0.095,P=0.76;χ^(2)=0.86,P=0.354);人口密度中等的FT街道阳性率低于人口密集的FZ街道和人口密度低的乡镇地区WZ镇(χ^(2)=9.55,P=0.002;χ^(2)=6.80,P=0.009);托幼机构和小学均表现出低年级阳性率较高的现象(托幼机构3~4岁组阳性率13.33%,5~6岁组阳性率2.44%;小学6~7岁组阳性率11.11%,8~9岁组未检出阳性)。不同性别、机构、街镇的诺如病毒检出率均无统计学差异。腺病毒和星状病毒仅在托幼儿童中检出。调查后一个月内所有调查对象涉及的班级均无急性胃肠炎疫情发生。There are few research reports on asymptomatic infection of diarrhea related viruses in childcare institutions and young school-age children.This study selected 460 children aged 3-9 from three districts who did not show symptoms of acute gastroenteritis within 4 weeks.Fecal specimens were collected and real-time RTPCR detection kit was used to detect five types of diarrhea viruses(norovirus,rotavirus,sapovirus,astrovirus and adenovirus).This study revealed that the asymptomatic infection rate of diarrhea virus in children was 8.26%(38/460),with the highest asymptomatic infection rate of Norovirus being 3.26%(15/460),followed by adenovirus(2.61%,12/460),sapovirus(1.52%,7/460),astrovirus(0.43%,2/460),and mixed infection 0.43%(2/460).Rotavirus was not detected in this survey.There was no statistically significant difference in the asymptomatic infection rate among different genders and institutions(χ^(2)=0.095,P=0.76;χ^(2)=0.86,P=0.354).The positive rate in Fengtai district in Beijing with moderate population density is lower than that in Fangzhuang district in Beijing with dense population and Wangzuo district in Beijing with low population density(χ^(2)=9.55,P=0.002;χ^(2)=6.80,P=0.009).Both primary school and childcare institution showed higher positive rate in lower grades.The positive rate in the 3-4 year old group of childcare institutions is 13.33%,and the positive rate in the 5-6 year old group is 2.44%.The positive rate in the 6-7 age group of primary school is 11.11%,while no positive was detected in the 8-9 age group.There was no statistically significant difference in the positive rate of norovirus among different genders,institutions,and districts.Adenovirus and astrovirus were only detected in preschool children.Within one month after the investigation,there was no case of acute gastroenteritis in the classes involved by all survey subjects.

关 键 词：无症状感染 诺如病毒 札如病毒 腺病毒 星状病毒 轮状病毒 

分 类 号：R373.2[医药卫生—病原生物学]