循环miRNAs在COVID-19并发心血管系统疾病中的研究进展  

Research Progress in the Role of Circulating miRNAs in Cardiovascular System Diseases Complicated by COVID-19

作　　者：马明仁 焦丕奇 刘明浩 王昱喆 王菲 马凌 MA Mingren;JIAO Piqi;LIU Minghao;WANG Yuzhe;WANG Fei;MA Ling(Department of Cardiology,the 940th Hospital of Joint Logistics Support Force of Chinese PLA,Lanzhou 730050,China;Department of Cardiology,Fuwai Hospital,National Center of Cardiovascular Disease,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China;The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院心血管内科,兰州730050 [2]中国医学科学院、北京协和医学院国家心血管病中心阜外医院心血管内科,北京100037 [3]甘肃中医药大学第一临床医学院,兰州730000

出　　处：《病毒学报》2024年第5期1137-1150,共14页Chinese Journal of Virology

基　　金：甘肃省自然科学基金(项目号:GSWSKY2023-47),题目:SARS-CoV-2 S蛋白通CyPa/CD147激活TLR3信号通路诱发心肌炎的机制研究;甘肃省自然科学基金(项目号:21JR1RA181),题目:COVID-19靶向CyPa/CD147信号通路诱导心肌细胞凋亡机制研究。

摘　　要：新型冠状病毒感染疫情对全球医疗救治体系提出了前所未有的严峻考验,尽管当前疫情传播得到有效控制,但是新型冠状病毒感染相关并发症以及“长新冠综合征”给健康带来的负面效应仍不容忽视,尤其是心血管循环系统更是严重急性呼吸综合征冠状病毒2易感的靶器官。微小RNA是调节重要生物学进程的内源性小分子单链非编码RNA,已证实微小RNA在心血管疾病的发生发展进程中扮演重要角色,并且循环微小RNA差异表达与新型冠状病毒感染并发心血管系统疾病密切相关,然而循环微小RNA在疾病病理进展中的作用机制尚不明确。因此,本文综述了循环微小RNA在新型冠状病毒感染并发心血管系统疾病中的作用及相关机制,同时对基于循环微小RNA为靶点的诊疗策略进行展望,以期为新型冠状病毒感染并发心血管系统疾病的防治提供新思路。The coronavirus disease 2019(COVID-19)epidemic has presented a significant challenge to global healthcare systems.Despite successful containment efforts,the adverse effects of the complications associated with COVID-19 and“long COVID-19”syndrome on health(particularly on the cardiovascular circulatory system)should not be overlooked.MicroRNAs are endogenous small-molecule,single-stranded non-coding RNAs.They play a crucial part in regulating essential biological processes.The importance of microRNAs in the pathogenesis of cardiovascular diseases has been established.Their differential expression in the circulation is closely associated with cardiovascular complications in COVID-19.However,the precise contribution of circulating microRNAs to disease progression is not known.Herein,we provide a comprehensive review of the involvement of circulating microRNAs in COVID-19 complicated by cardiovascular diseases.We examined the underlying mechanisms and proposed potential diagnostic and therapeutic strategies targeting circulating microRNAs.In this way,we proposed innovative strategies for the prevention and management of cardiovascular diseases in the context of COVID-19.

关 键 词：微小RNA 循环miRNA 新型冠状病毒 新型冠状病毒感染 心血管系统疾病 

分 类 号：R373[医药卫生—病原生物学]