HIV潜伏库形成与维持机制的研究进展  

Research Progress on the Mechanism of the Formation and Maintenance of Latent HIV Reservoirs

作　　者：易立政 邓博文[1,2,3] 张清燕 桑锋 刘真[1,2,3] 岳静宇 钱洁玉[1,2,3] 李强 李杰[1,2,3] YI Lizheng;DENG Bowen;ZHANG Qingyan;SANG Feng;LIU Zhen;YUE Jingyu;QIAN Jieyu;LI Qiang;LI Jie(AIDS Clinical Research Center,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Clinical Medical College of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Henan Provincial Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of Viral Diseases,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学第一附属医院艾滋病临床研究中心,郑州450000 [2]河南中医药大学第一临床医学院,郑州450000 [3]河南省病毒性疾病中医药防治重点实验室,郑州450000

出　　处：《病毒学报》2024年第5期1173-1179,共7页Chinese Journal of Virology

基　　金：国家自然科学基金(项目号:82104559),题目:基于CCL25-CCR9信号通路调节肠淋巴细胞归巢探讨健脾益气方干预HIV/AIDS肠黏膜免疫屏障的作用机制;河南省重点研发与推广专项课题(项目号:232102311222),题目:清肺培元方通过抑制中性粒细胞胞外陷阱治疗HIV肺部感染的比较研究;河南省中医管理局国家中医临床研究基地专项课题(项目号:2021JDZY008),题目:基于miR124/c-myc信号轴探讨益艾康对HIV/AIDS患者NK细胞的调控作用;河南省科技攻关(项目号:242102310519),题目:基与线粒体质量控制介导CD4+T细胞自噬流探讨健脾益气方改善HIV/AIDS患者免疫重建的机制;河南省科技攻关(项目号:242102310314),题目:基于miR145/CD40信号轴探讨健脾益气方调控HIV潜伏病毒库的作用机制;河南省科技攻关(项目号:232102310462),题目:益艾康干预HIV病毒储存库调节HIV/AIDS患者免疫功能的疗效评价研究。

摘　　要：人体感染人类免疫缺陷病毒(Human immunodeficiency virus,HIV)后,虽然抗逆转录病毒疗法(Antiretroviral therapy,ART)可有效控制病毒复制,却无法彻底清除HIV,这主要是由于潜伏病毒库的存在。HIV潜伏库是目前治愈HIV感染的主要挑战,其形成及维持机制是近几年的研究热点,本文从HIV RNA代谢角度探讨HIV潜伏库的形成机制、从细胞克隆扩增方面分析HIV潜伏库的维持机制,并对HIV RNA代谢和克隆扩增途径治愈HIV潜伏库的研究进展进行系统综述,以期为根除潜伏病毒提供新思路。After Human immunodeficiency virus(HIV) infection, although antiretroviral therapy can control viral replication effectively, it cannot eliminate HIV completely, This drawback is due mainly to the existence of “latent viral reservoirs”, which are the main challenge for the cure of HIV infection. The mechanisms underlying formation and maintenance of latent HIV reservoirs(LHRs) have become research “hotspot” in recent years. Herein, we discuss the formation mechanism of LHRs from the perspective of the metabolism of HIV RNA, we analyzed the maintenance mechanism of LHRs from the aspect of cellular clonal expansion, we conducted a systematic review of research progress of curing LHRs by the pathways of HIV RNA metabolism and clonal expansion. Our review can provide new ways of thinking for LHRs eradication.

关 键 词：HIV 潜伏病毒库 RNA代谢 克隆扩增 维持机制 

分 类 号：R512.91[医药卫生—内科学]