血液病房产超广谱β-内酰胺酶菌分布情况及药物敏感性分析  

Distribution and drug sensitivity analysis of ultra-broad spectrumβ-lactamase in real estate with blood disease

作　　者：欧阳贤凤[1] 罗萍[1] 胡飞[1] 刘丹[1] 汤金萍[1] 李金凤[1] 郭瑛[1] 赵娜[1] OUYANG Xianfeng;LUO Ping;HU Fei;LIU Dan;TANG Jinping;LI Jinfeng;GUO Ying;ZHAO Na(Department of Hematology,the First People's Hospital of Jiujiang City,Jiangxi Province,Jiujiang 332000,China)

机构地区：[1]江西省九江市第一人民医院血液内科,江西九江332000

出　　处：《中国当代医药》2024年第25期39-42,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(20204207)。

摘　　要：目的分析2020年1月至2021年11月江西省九江市第一人民医院(以下简称“本院”)血液病房产超广谱β-内酰胺酶(ESBLs)菌分布情况及药物敏感性。方法选取2020年1月至2021年11月江西省九江市第一人民医院血液病房138例患者作为研究对象,收集患者的分泌物进行病原菌培养,并对产ESBLs菌分布情况和药物敏感性进行分析。结果革兰氏阴性菌居多,共分离出160株,占比80.00%,其次是真菌和革兰氏阳性菌,各分离出22株和18株。其中以铜绿假单胞菌、大肠埃希菌和肺炎克雷伯菌最为常见。本院血液病房病原菌共检出200株,检出情况主要以痰、中段尿、咽拭子居多,以肛拭子、大便检出较少;200株病原菌共检出产ESBLs菌56株,占比28.00%,以中段尿、咽拭子检出居多,脓液、肛拭子、大便中未检出。本院血液病房产ESBLs菌除对亚胺培南、美罗培南耐药率较低外,对大部分抗菌药物的耐药率均较高。结论本院血液病原菌以革兰氏阴性菌为主,且对抗菌药物的耐药率较高,临床应重点关注此类菌株感染,需引起重视,加强院感的防控,避免发生耐药菌的暴发和流行。Objective To analyze the distribution and drug sensitivity of extended-spectrumβ-lactamase(ESBLs)bacteria in the real estate of blood diseases in the First People's Hospital of Jiujiang City(hereinafter referred to as"our hospital")from January 2020 to November 2021.Methods A total of 138 patients in the hematology ward of our hospital from January 2020 to November 2021 were selected as the study objects.Secretions of patients were collected for pathogen culture,and the distribution and drug sensitivity of ESBLs-producing bacteria were analyzed.Results The majority of Gram-negative bacteria were isolated with 160 isolates,accounting for 80.00%,followed by fungi and Gram-positive bacteria with 22 isolates and 18 isolates respectively.Among them,pseudomonas aeruginosa,escherichia coli and klebsiella pneumoniae were the most common.A total of 200 strains of pathogenic bacteria were detected in the hematology ward of our hospital,mainly in sputum,midstream urine,throat swab,and less in anal swab and stool.A total of 56 strains of ESBLs were detected from 200 pathogens,accounting for 28.00%.Most of them were detected from midstream urine and throat swab,but none were detected from pus,anal swab and stool.In addition to the low resistance rate to imipenem and meropenem,the resistance rate to most antibiotics of ESBLs bacteria in our hospital was high.Conclusion The blood pathogens in our hospital are mainly Gram-negative bacteria,and the resistance rate to antibiotics is high.Clinical attention should be paid to the infection of such strains,which should be paid to the prevention and control of hospital infection to avoid the outbreak and epidemic of drug-resistant bacteria.

关 键 词：超广谱Β-内酰胺酶 病原菌分布 药物敏感性 抗菌药物 

分 类 号：R446[医药卫生—诊断学]