晚期早产适于胎龄儿宫外生长迟缓的危险因素分析  

Analysis on risk factors of extrauterine growth retardation for late preterm infants appropriate for gestational age

作　　者：王永明 许梅 马海佳 李虹 吴路江 朱雪琴 马利勇 吴梦思 薛三相 罗靖侠 WANG Yongming;XU Mei;MA Haijia;LI Hong;WU Lujiang;ZHU Xueqin;MA Liyong;WU Mengsi;XUE Sanxiang;LUO Jingxia(Department of Neonatology,Yinchuan Municipal Maternal and Child Healthcare Hospital,Yinchuan,Ningxia 750000,China)

机构地区：[1]银川市妇幼保健院新生儿科,银川750000

出　　处：《重庆医学》2024年第19期2954-2959,共6页Chongqing Medical Journal

基　　金：宁夏自然科学基金项目(2022AAC03747)。

摘　　要：目的分析晚期早产儿适于胎龄儿宫外生长迟缓(EUGR)的危险因素。方法回顾性分析2016年1月至2022年6月于该院分娩收住新生儿科的1402例早产适于胎龄儿临床资料,依据芬顿(Fenton)早产儿生长曲线将出院时体重是否低于同期同胎龄生长曲线第10百分位分为EUGR组(n=244)和非EUGR组(n=1158)。收集两组早产儿及母亲临床资料,分析早产儿发生EUGR的危险因素。结果1402例早产适于胎龄儿中发生EUGR 244例,EUGR发生率为17.4%。不同胎龄早产儿EUGR发生率比较,差异无统计学意义(P>0.05)。不同出生体重早产儿EUGR发生率比较,差异有统计学意义(P<0.05)。logistic回归分析显示,男性(OR=1.694,95%CI:1.144~2.507)、出生体重低(OR=0.989,95%CI:0.988~0.991)、喂养不耐受(OR=2.719,95%CI:1.234~5.990)、孕周短(OR=0.146,95%CI:0.103~0.207)、住院时间延长(OR=1.073,95%CI:1.031~1.117)为晚期早产适于胎龄儿出院时发生EUGR的危险因素(P<0.05)。亚组分析显示,男性、出生体重低、喂养不耐受、住院时间长为34~<36周早产适于胎龄儿出院时发生EUGR的危险因素(P<0.05),出生体重低、喂养不耐受只影响胎龄≥36周早产儿(P<0.05)。结论加强孕期保健、生后积极营养支持可降低晚期早产儿EUGR的发生风险。Objective To analyze the risk factors for extrauterine growth retardation(EUGR)in late preterm infants appropriate for gestational age.Methods The clinical data in 1402 preterm infants appropriate for gestational age delivered and hospitalized in this hospital from January 2016 to June 2022 were analyzed retrospectively.They were divided into the EUGR group(n=244)and the non-EUGR group(n=1158)according to whether or not the body weight at discharge was below the 10th percentile of the growth curve for the same gestational age at the same period based on the Fenton’s preterm growth curve.The clinical data of preterm infants and mothers of the two groups were collected.The risk factors for EUGR occurrence in premature infants were analyzed.Results Among 1402 preterm infants appropriate for gestational age,EUGR occurred in 244 cases with the EUGR incidence rate of 17.4%.The EUGR incidence rate had no statistical difference among the different fetal ages of premature infants(P>0.05).The EUGR incidence rate had statistical difference among different birth weights of premature infants(P<0.05).The logistic regression analysis showed that male(OR=1.694,95%CI:1.144-2.507),low birth weight(OR=0.989,95%CI:0.988-0.991),feeding intolerance(OR=2.719,95%CI:1.234-5.990),short gestational weeks(OR=0.146,95%CI:0.103-0.207)and hospitalization duration extension(OR=1.073,95%CI:1.031-1.117)were the risk factors for EUGR occurrence in late premature infants appropriate for gestational age in discharge.The subgroup analysis showed that male,low birth weight,feeding intolerance and hospitalization duration extension were the risk factors for EUGR occurrence in the preterm infants with gestational ages of 34-<36 weeks(P<0.05).Low birth weight and feeding intolerance only affected the preterm infants≥36 weeks of gestational age(P<0.05).Conclusion Strengthening the pregnant duration health care and active nutritional support after birth may reduce the risk of EUGR occurrence in late premature infants.

关 键 词：新生儿 晚期早产儿 适于胎龄儿 宫外生长迟缓 危险因素 

分 类 号：R722.6[医药卫生—儿科]