垂体神经内分泌肿瘤侵袭性相关生物标志物的研究进展  

Research progress on biomarkers related to aggressiveness in pituitary neuroendocrine tumors

作　　者：张港 邵川 吴南 ZHANG Gang;SHAO Chuan;WU Nan(Chongqing Medical University,Chongqing 400016,China;Department of Neurosurgery,Chongqing General Hospital,Chongqing 401147,China)

机构地区：[1]重庆医科大学,重庆400016 [2]重庆市人民医院神经外科,重庆401147

出　　处：《重庆医学》2024年第19期3024-3028,共5页Chongqing Medical Journal

基　　金：重庆市科学技术局基金项目(CSTB2022NSCQ-MSX0548)。

摘　　要：可靠的生物标志物对侵袭性垂体神经内分泌肿瘤(PitNETs)的早期诊断、有效治疗和预后评估非常重要。随着研究的积累,临床对于PitNETs的发生和发展过程已经有了更深入的了解,许多能够参与PitNETs侵袭性生长的生物分子已被报道。但由于PitNETs各亚型间异质性较大,涉及多维度高复杂性的调控网络,目前能够应用于临床诊疗的生物标志物仍十分稀少。该文对PitNETs侵袭性相关的生物标志物展开综述,进一步阐述PitNETs侵袭性背后的机制,为寻找PitNETs诊断、治疗及预后评估的靶点提供了思路。Reliable biomarkers are very important for early diagnosis,effective treatment and prognostic assessment of aggressive pituitary neuroendocrine tumors(PitNETs).With the accumulation of researches,the occurrence and development of PitNETs have been better understood,and many biomolecules that can participate in the aggressive growth of PitNETs have been reported.However,due to the large heterogeneity among the subtypes of PitNETs and the involvement of multi-dimensional and highly complex regulatory networks,there are still very few biomarkers that can be applied to clinical diagnosis and treatment.This article reviews the biomarkers related to the invasiveness of PitNETs,further elaborates the mechanism behind the invasiveness of PitNETs,and provides the ideas for finding the target spots for the diagnosis,treatment and prognosis evaluation of PitNETs.

关 键 词：垂体神经内分泌肿瘤 侵袭性 生物标志物 亚型 综述 

分 类 号：R181[医药卫生—流行病学]