0.1 mg/kg纳布啡复合依托咪酯麻醉对无抽搐电休克治疗患者血流动力学指标及安全性的影响  

Effect of 0.1 mg/kg Nalbuphine combined with Etomidate anesthesia on hemodynamic parameters and safety in patients undergoing non convulsive electroconvulsive therapy

作　　者：张荣洪 龙胜平 ZHANG Ronghong;LONG Shengping(Department of Anesthesiology,the Third People's Hospital of Ganzhou,Jiangxi Province,Ganzhou341000,China;Department of Anesthesiology,Longnan First People's Hospital,Jiangxi Province,Ganzhou341700,China)

机构地区：[1]江西省赣州市第三人民医院麻醉科,江西赣州341000 [2]江西省龙南市第一人民医院麻醉科,江西赣州341700

出　　处：《中国当代医药》2024年第26期80-83,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202312062)。

摘　　要：目的探讨0.1 mg/kg纳布啡复合依托咪酯麻醉对无抽搐电休克(MECT)治疗患者血流动力学指标及安全性的影响。方法选取2022年3月至2023年10月赣州市第三人民医院接受MECT治疗的96例患者作为研究对象,以抽签法分为对照组(32例)、研究1组(32例)、研究2组(32例)。对照组采用2 ml生理盐水+依托咪酯麻醉,研究1组采用0.05 mg/kg纳布啡+依托咪酯麻醉,研究2组采用0.1 mg/kg纳布啡+依托咪酯麻醉。比较三组麻醉前(T_(0))、麻醉诱导后(T_(1))、MECT治疗后5 min(T_(2))、MECT治疗结束时(T_(3))的血流动力学指标[平均动脉压(MAP)、心率(HR)]、苏醒质量、肌阵挛程度及不良反应。结果研究1组、研究2组T_(1)~T_(3)时的MAP、HR低于对照组,差异有统计学意义(P<0.05)。三组的意识恢复及自主呼吸恢复时间比较,差异无统计学意义(P>0.05);研究2组肌阵挛程度轻于研究1组、对照组,差异有统计学意义(P<0.05);研究2组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论MECT治疗患者采用0.1 mg/kg纳布啡复合依托咪酯麻醉可稳定血流动力学,减轻肌阵挛程度,减少不良反应发生,且对苏醒质量影响小。Objective To explore the effect of 0.1 mg/kg Naborphanine combined with Etomidate anesthesia on hemodynamic indicators and safety in patients undergoing non convulsive electroconvulsive therapy(MECT).Methods A total of 96 patients who received MECT treatment in the Third People's Hospital of Ganzhou from March 2022 to October 2023 were selected as the study objects and divided into control group(32 cases),study group 1(32 cases)and study group 2(32 cases)by drawing lots.The control group was anesthetized with 2 ml of physiological saline and Etomidate.Study group 1 was anesthetized with 0.05 mg/kg of Nalbuphine and Etomidate,while study group 2 was anesthetized with 0.1 mg/kg of Nalbuphine and Etomidate.The hemodynamic indexes(mean arterial pressure[MAP],heart rate[HR])before anesthesia(T_(0)),after anesthesia induction(T_(1)),5 min after MECT treatment(T_(2)),and at the end of MECT treatment(T_(3)),quality of recovery,myoclonus degree and adverse reactions of the three groups were compared.Results MAP and HR of T_(1)~T_(3)in study group 1 and study group 2 were lower than those in control group,and the difference was statistically significant(P<0.05).There was no significant difference in the recovery time of consciousness and spontaneous respiration among the three groups(P>0.05).The severity of myoclonus in study group 2 was less than that in study group 1 and control group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in study group 2 was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion The use of 0.1 mg/kg Nalbuphine combined with Etomidate anesthesia in patients undergoing MECT treatment can stabilize hemodynamics,reduce the severity of myoclonus,reduce the occurrence of adverse reactions,and have little impact on awakening quality.

关 键 词：无抽搐电休克 纳布啡 依托咪酯 血流动力学指标 

分 类 号：R614[医药卫生—麻醉学]