健脾祛湿汤联合川百止痒洗剂治疗小儿脾虚湿蕴型湿疹的临床研究  

Clinical study on the combination of Jianpi Qushi Decoction and Chuanbai Zhiyang Lotion in the treatment of pediatric eczema with spleen deficiency and dampness accumulation type

作　　者：刘娜 刘美霞 LIU Na;LIU Meixia(Traditional Chinese Medicine Room,Jiujiang Third People's Hospital,Jiangxi Province,Jiujiang332000,China)

机构地区：[1]江西省九江市第三人民医院中药房,江西九江332000

出　　处：《中国当代医药》2024年第27期112-115,120,共5页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2023B1343)。

摘　　要：目的探讨小儿脾虚湿蕴型湿疹应用健脾祛湿汤联合川百止痒洗剂治疗的效果。方法选取2021年5月至2023年12月九江市第三人民医院收治的68例脾虚湿蕴型湿疹患儿为研究对象,采用随机数字表法分为对照组和观察组,各34例。对照组采用川百止痒洗剂治疗,观察组在对照组基础上加用健脾祛湿汤治疗,两组均连续治疗4周。比较两组的临床疗效、湿疹面积及严重度指数(EASI)评分、瘙痒程度积分、中医症状积分、炎症因子水平、复发率及不良反应。结果观察组的治疗总有效率高于对照组,复发率低于对照组,差异有统计学意义(P<0.05);两组治疗前的EASI评分、瘙痒程度积分、中医症状积分及白介素-4(IL-4)、白介素-10(IL-10)水平比较,差异无统计学意义(P>0.05);观察组治疗后的EASI评分、瘙痒程度积分、中医症状积分及IL-4、IL-10水平低于对照组,差异有统计学意义(P<0.05);两组均未见明显不良反应。结论健脾祛湿汤与川百止痒洗剂联合应用于小儿脾虚湿蕴型湿疹治疗效果确切,可缩小湿疹面积,减轻瘙痒程度及机体炎症反应,降低复发率,值得临床推广应用。Objective To explore the therapeutic effect of Jianpi Qushi Decoction combined with Chuanbai Zhiyang Lotion on children with spleen deficiency and dampness accumulation type eczema.Methods A total of 68 children with spleen deficiency and dampness accumulation type eczema treated in Jiujiang Third People's Hospital from May 2021 to December 2023 were selected as the study objects,and were divided into control group and observation group by random number table method,with 34 cases in each group.The control group was treated with Chuanbai Zhiyang Lotion,and the observation group was treated with Jianpi Qushi Decoction on the basis of the control group.Both groups were treated continuously for 4 weeks.Clinical efficacy,eczema area and severity index(EASI)score,itch degree score,traditional Chinese medicine symptom score,inflammatory factor level,recurrence rate and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the recurrence rate was lower than that of the control group,with statistically significant differences(P<0.05).There was no significant difference in EASI score,itch degree score,traditional Chinese medicine symptom score and interleukin-4(IL-4)and interleukin-10(IL-10)levels between the two groups before treatment(P>0.05).EASI score,itch degree score,traditional Chinese medicine symptom score and IL-4 and IL-10 levels in the observation group were lower than those in the control group after treatment,and the differences were statistically significant(P<0.05).No significant adverse reactions were observed in both groups.Conclusion The combination of Jianpi Qushi Decoction and Chuanbai Zhiyang Lotion has a definite therapeutic effect on children with spleen deficiency and dampness accumulation type eczema.It can reduce the area of eczema,alleviate the degree of itching,and reduce the recurrence rate.It is worthy of clinical promotion and application.

关 键 词：小儿湿疹 脾虚湿蕴型 健脾祛湿汤 川百止痒洗剂 瘙痒 皮损 复发 

分 类 号：R751[医药卫生—皮肤病学与性病学]