NLRP3炎症小体的激活在骨关节疾病中的研究进展  

Research progress on activation of NLRP3 inflammasome in bone and joint diseases

作　　者：张浩(综述)[1] 段力军(审校) ZHANG Hao;DUAN Lijun(Inner Mongolia Medical University,Hohhot,Inner Mongolia 010110,China;Department of Orthopedic Surgery,Beijing Sijiqing Hospital,Beijing 100089,China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010110 [2]北京四季青医院骨外科,北京100089

出　　处：《现代医药卫生》2024年第19期3375-3380,共6页Journal of Modern Medicine & Health

摘　　要：炎症是对多种刺激的关键反应,细胞因子等炎症分子在包括骨和关节疾病在内的多种疾病的发病机制中发挥核心作用。促炎性细胞因子主要由免疫细胞产生,介导炎症和先天免疫反应。炎症小体是新近公认的先天免疫的重要参与者。最典型的是NOD样受体蛋白3(NLRP3)炎症小体,NLRP3检测外源性致病性侵袭和内源性细胞损伤,并通过形成NLRP3炎症小体做出反应。NLRP3炎症小体的3个主要成分是NLRP3(捕获危险信号并募集下游分子)、半胱氨酸天冬氨酸蛋白水解酶-1[caspase-1,引起细胞因子白细胞介素-1β(IL-1β)和IL-18的成熟以介导细胞因子释放和焦亡]和含有半胱天冬酶募集结构域的细胞凋亡相关斑点样蛋白(ASC,是连接NLRP3和caspase-1的桥梁)。此外,促炎性细胞因子加速骨吸收和软骨破坏,导致骨和关节组织破坏。因此,促炎性细胞因子参与调节骨和关节疾病的发病机制。该文综述了近年来关于NLRP3炎症小体在骨关节疾病中激活和功能等方面的研究进展。Inflammation is a key response to a variety of stimuli,and inflammatory molecules such as cytokines play a central role in the pathogenesis of many diseases,including bone and joint diseases.Proinflammatory cytokines are mainly produced by immune cells,which mediate inflammation and innate immune responses.Inflammasomes are newly recognized as important players in innate immunity.The most typical one is the NOD-like receptor protein 3(NLRP3)inflammasome.NLRP3 detects exogenous pathogenic invasion and endogenous cell damage and responds by forming the NLRP3 inflammasome.The three main components of the NLRP3 inflammasome are NLRP3(capturing danger signals and recruits downstream molecules),caspase-1(inducing the maturation of cytokines IL-1βand IL-18 to mediate the release and focal death of cytokines)and apoptosis-related spot-like protein containing caspase recruitment domain(ASC,which connects NLRP3 and caspase-1).In addition,proinflammatory cytokines accelerate bone absorption and cartilage destruction,leading to bone and joint tissue destruction.Therefore,proinflammatory cytokines are involved in regulating the pathogenesis of bone and joint diseases.This paper reviewed the research progress on the activation and function of NLRP3 inflammatory corpuscles in bone and joint diseases in recent years.

关 键 词：白细胞介素-1 炎症小体 NOD样受体蛋白3 骨关节炎 骨质疏松 骨关节疾病 综述 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]