铁死亡在脓毒症心肌损伤中的研究进展  

Research progress on ferroptosis in sepsis induced myocardial injury

作　　者：李佳卓[1] 梁群[2] 姜芊竹[3] 王鑫 巩菲菲[3] 郭丹丹[3] LI Jiazhuo;LIANG Qun;JIANG Qianzhu;WANG Xin;GONG Feifei;GUO Dandan(The First School of Clinical Medicine,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin 150040,China;Department of Emergency and Critical Care Medicine,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin 150040,China;Department of Cardiology,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin 150001,China;Department of Intensive Care Rehabilitation,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学第一临床医学院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院急诊及重症医学科,黑龙江哈尔滨150040 [3]黑龙江中医药大学附属第二医院心内科,黑龙江哈尔滨150001 [4]黑龙江中医药大学附属第二医院重症康复科,黑龙江哈尔滨150001

出　　处：《中国医药导报》2024年第24期40-44,共5页China Medical Herald

基　　金：国家自然科学基金项目(81974557);黑龙江省中医药管理局科研课题(ZHY2023-230);黑龙江省中医药管理局第二批中医临床优秀人才培养项目(黑中医药教函〔2022〕28号);黑龙江中医药大学科研基金项目(201833)。

摘　　要：铁死亡是一种与铁积累和脂质过氧化相关的程序性细胞死亡形式,具有独特的形态、遗传和生化特征。脓毒症是一种危及生命的多器官功能障碍综合征,由人体对感染的免疫反应失调引起。脓毒症心肌损伤是脓毒症的一种严重并发症,是加剧患者死亡的重要因素,给社会和家庭造成极大负担。铁死亡与脓毒症心肌损伤的发生密切相关。本文对铁死亡与脓毒症心肌损伤的机制进行综述,探讨铁死亡在脓毒症心肌损伤中的研究进展,以期为脓毒症心肌损伤的治疗提供新思路。Ferroptosis is a form of programmed cell death which is associated with iron accumulation and lipid peroxidation by unique morphological,genetic and biochemical characteristics.Sepsis is a life-threatening multiple organ dysfunction syndrome caused by an imbalance in the body’s immune response to infection.Sepsis induced myocardial injury is a serious complication of sepsis and an important factor exacerbating patient mortality,causing great burden on society and families.Ferroptosis is closely related to the occurrence of sepsis induced myocardial injury.This article reviews the mechanisms of ferroptosis and sepsis induced myocardial injury,and explores research progress of ferroptosis in sepsis induced myocardial injury,in order to provide new ideas for the treatment of sepsis induced myocardial injury.

关 键 词：铁死亡 脓毒症心肌损伤 脂质代谢 氧化应激 线粒体功能障碍 炎症反应 

分 类 号：R542.2[医药卫生—心血管疾病]