miR-10b在细胞衰老中的研究进展  

Research progress of miR-10b in cellular senescence

作　　者：韩若梦 瞿媛[2] HAN Ruomeng;QU Yuan(Graduate School,Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing 210022,China;Department of Emergency,Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Jiangsu Province,Nanjing 210022,China)

机构地区：[1]南京中医药大学研究生院,江苏南京210022 [2]南京中医药大学附属南京中医院急诊科,江苏南京210022

出　　处：《中国医药导报》2024年第24期63-67,共5页China Medical Herald

基　　金：第三批江苏省老中医药专家学术经验继承工作项目(苏中医科教〔2019〕8号);江苏省南京市中医药传承创新发展示范试点项目(宁卫财务〔2024〕8号);江苏省南京市中医药科技专项项目(ZYQN202207)。

摘　　要：细胞衰老被描述为一种细胞周期的永久停滞状态,既可延缓肿瘤等增生性病理进展,又可加速机体衰老的退行性病变进程。鉴于细胞衰老在诸多年龄相关疾病中的关键作用,量化和评估衰老水平的标志物仍在探索。微RNA调节与衰老相关疾病的发生及发展关系密切。包括miR-10b在内的微RNA通过调节细胞周期、端粒酶活性、自由基水平和线粒体功能等方式参与细胞衰老的过程,并发挥有益或有害作用。本文对细胞衰老定义与机制、miR-10b与其调控细胞衰老的机制及中医药作用于miR-10b的机制等进行综述,探讨miR-10b作为预测和评估细胞衰老的生物标志物及治疗潜在靶点的可行性。Cellular senescence is described as a permanent state of cell cycle arrest,which can delay the progression of proliferative pathology such as tumors and accelerate the degenerative process of aging in the body.Given the crucial role of cellular senescence in many age-related diseases,biomarkers for quantifying and evaluating aging levels are still being explored.The microRNA regulation is closely related to occurrence and development of age-related diseases.The microRNA,including miR-10b,participate in the process of cellular senescence by regulating cell cycle,telomerase activity,free radical levels,and mitochondrial function,and exert beneficial or harmful effects.This article reviews definition and mechanism of cellular senescence,miR-10b and its regulation of cellular aging,as well as the mechanism of traditional Chinese medicine acting on miR-10b.It explores the feasibility of miR-10b as a biomarker and potential therapeutic target for predicting and evaluating cellular senescence.

关 键 词：MIR-10B 微RNA 细胞衰老 中医药 

分 类 号：R592[医药卫生—老年医学]