循环游离DNA在肾脏疾病中的研究进展  

Research progress of circulating free DNA in kidney diseases

作　　者：王学良 苑书婷 李甜[1] 席春生 WANG Xueliang;YUAN Shuting;LI Tian;XI Chunsheng(The First Clinical Medical College of Gansu University of Chinese Medicine,Gansu Province,Lanzhou 730000,China;Department of Nephrology,the 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army,Gansu Province,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]中国人民解放军联勤保障部队第九四〇医院肾脏病科,甘肃兰州730050

出　　处：《中国医药导报》2024年第24期68-73,共6页China Medical Herald

基　　金：甘肃省卫生健康行业科研计划项目(GSWSKY 2022-51);甘肃省兰州市科技计划项目(2023-ZD-173)。

摘　　要：肾脏疾病是一类严重威胁人类健康的疾病,其发病率及死亡率高,寻求高灵敏度的生物学指标有助于早期诊断和改善预后。循环游离DNA是一类存在于血浆、尿液及其他体液中游离于细胞外的双链DNA片段。循环游离DNA参与机体内在的炎症反应和凝血过程,在肾脏疾病中显著升高,可作为肾脏疾病的潜在生物标志物,对疾病的诊断和预后有重大意义。本文对循环游离DNA的生物学特性、在肾脏疾病中的作用及应用进展进行综述,以期为肾脏疾病的早期诊断及预后提供参考。Kidney disease is a kind of disease that seriously threatens human health,its incidence rate and mortality rate are high,seeking high sensitive biological indicators is helpful to early diagnosis and improve prognosis.Circulating free DNA is a type of double stranded DNA fragment that exists outside of cells in plasma,urine,and other body fluids.Circulating free DNA is involved in the body’s intrinsic inflammatory response and coagulation process,and is significantly elevated in kidney disease,which can used as a potential biomarker for kidney disease and has significant implications for disease diagnosis and prognosis.This article reviews biological characteristics role and application progress in kidney diseases of circulating free DNA,in order to provide reference for early diagnosis and prognosis of kidney diseases.

关 键 词：循环游离DNA 肾脏疾病 生物标志物 诊断及预后 

分 类 号：R692[医药卫生—泌尿科学]